ghra growth hormone receptor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ghraprovided by ZNC
Official Full Name: growth hormone receptor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070509-1
See related: Ensembl:ENSDARG00000054771 AllianceGenome:ZFIN:ZDB-GENE-070509-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ghr; ghr.a; zgc:162141
Summary: Predicted to enable several functions, including growth factor binding activity; growth hormone receptor activity; and peptide hormone binding activity. Predicted to be involved in cell surface receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within endocytosis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of growth hormone receptor complex. Predicted to be active in cytosol and external side of plasma membrane. Is expressed in several structures, including lens; liver; notochord; pleuroperitoneal region; and yolk. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (31465222..31606409, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (31455990..31597177, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reproductive tests showed that double transgenic males did not differ from non-transgenics. It is possible that GHR excess in the muscle tissues of double transgenics may have contributed to lower circulating GH levels and thus reduced the negative effects of this hormone with respect to reproduction.
Title: Reproductive parameters of double transgenic zebrafish (Danio rerio) males overexpressing both the growth hormone (GH) and its receptor (GHR).
that concomitant overexpression of GH and GHR resulted in a strong decrease of the somatotrophic axis intracellular signaling by diminishing its principal transcription factor signal transducer and activator of transcription 5.1.
Title: Effects of Double Transgenesis of Somatotrophic Axis (GH/GHR) on Skeletal Muscle Growth of Zebrafish (Danio rerio).
GHR nuclear translocation is associated with muscle cell proliferation in zebrafish.
Title: High level of GHR nuclear translocation in skeletal muscle of a hyperplasic transgenic zebrafish.
Effects of somatotrophic axis (GH/GHR) double transgenesis on structural and molecular aspects of the zebrafish immune system
Title: Effects of somatotrophic axis (GH/GHR) double transgenesis on structural and molecular aspects of the zebrafish immune system.
Hypertrophy and hyperplasia follow two different routes for muscle growth, both of them triggered by GHR activation.
Title: Muscle-specific growth hormone receptor (GHR) overexpression induces hyperplasia but not hypertrophy in transgenic zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in growth hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of growth hormone receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth hormone receptor a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083578.1 → NP_001077047.1 growth hormone receptor a precursor

See identical proteins and their annotated locations for NP_001077047.1

Status: PROVISIONAL

Source sequence(s)

BC134903

UniProtKB/TrEMBL

A4IG30

Related

ENSDARP00000014290.8, ENSDART00000018886.9

Conserved Domains (3) summary

cd00063
Location:136 → 234

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12772
Location:300 → 507

GHBP; Growth hormone receptor binding

cl21522
Location:37 → 122

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...