dph7 diphthamide biosynthesis 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dph7provided by ZNC
Official Full Name: diphthamide biosynthesis 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-070410-57
See related: Ensembl:ENSDARG00000062083 AllianceGenome:ZFIN:ZDB-GENE-070410-57
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wdr85; zgc:162277
Summary: Predicted to enable diphthine methylesterase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to act upstream of or within methylation. Predicted to be active in cytoplasm. Orthologous to human DPH7 (diphthamide biosynthesis 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (25077212..25084318, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (24573412..24580548, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables diphthine methylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphthine methylesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in protein histidyl modification to diphthamide	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: diphthine methyltransferase

Names: WD repeat domain 85

NP_001076308.1

EC 3.1.1.97

XP_005165231.1

EC 3.1.1.97

XP_021331937.1

EC 3.1.1.97

XP_068077344.1

EC 3.1.1.97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082839.1 → NP_001076308.1 diphthine methyltransferase

See identical proteins and their annotated locations for NP_001076308.1

Status: PROVISIONAL

Source sequence(s)

BC133930

UniProtKB/TrEMBL

A0A8M1ND87, A3KNN6

Related

ENSDARP00000083772.4, ENSDART00000089339.5

Conserved Domains (3) summary

COG2319
Location:54 → 304

WD40; WD40 repeat [General function prediction only]

sd00039
Location:90 → 139

7WD40; WD40 repeat [structural motif]

cl02567
Location:192 → 313

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

25077212..25084318 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476262.2 → XP_021331937.1 diphthine methyltransferase isoform X1

UniProtKB/TrEMBL

A0A8M9PKE8

Conserved Domains (2) summary

COG2319
Location:47 → 303

WD40; WD40 repeat [General function prediction only]

sd00039
Location:89 → 138

7WD40; WD40 repeat [structural motif]
XM_005165174.5 → XP_005165231.1 diphthine methyltransferase isoform X2

UniProtKB/TrEMBL

A0A8M2BCI9

Conserved Domains (2) summary

sd00039
Location:90 → 139

7WD40; WD40 repeat [structural motif]

cl02567
Location:191 → 312

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_068221243.1 → XP_068077344.1 diphthine methyltransferase isoform X3