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    aftpha aftiphilin a [ Danio rerio (zebrafish) ]

    Gene ID: 556043, updated on 2-Nov-2024

    Summary

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    Official Symbol
    aftphaprovided by ZNC
    Official Full Name
    aftiphilin aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1437
    See related
    Ensembl:ENSDARG00000069249 AllianceGenome:ZFIN:ZDB-GENE-030131-1437
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb71f09; wu:fb71f09; CH73-131E21.7; si:ch73-131e21.7
    Summary
    Predicted to enable clathrin binding activity. Predicted to be involved in intracellular transport. Predicted to be part of AP-1 adaptor complex. Predicted to be active in trans-Golgi network membrane. Orthologous to human AFTPH (aftiphilin). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See aftpha in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (55095301..55110908)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (54417632..54433345)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene pellino E3 ubiquitin protein ligase 1a Neighboring gene lectin, galactoside-binding-like a Neighboring gene SERTA domain containing 2a Neighboring gene RAB1A, member RAS oncogene family a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Zhou S, et al. Fish Shellfish Immunol, 2016 Feb. PMID 26767746
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aftiphilin a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145561.1 → NP_001139033.1  aftiphilin a

      See identical proteins and their annotated locations for NP_001139033.1

      Status: PROVISIONAL

      Source sequence(s)
      CU467849
      UniProtKB/TrEMBL
      A0A8M1NRF7, B8JLD1
      Related
      ENSDARP00000117101.1, ENSDART00000132727.3
      Conserved Domains (2) summary
      PHA02664
      Location:366 → 482
      PHA02664; hypothetical protein; Provisional
      pfam15045
      Location:555 → 624
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      55095301..55110908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160172.5 → XP_005160229.1  aftiphilin a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B6Y9
      Conserved Domains (2) summary
      PHA02664
      Location:366 → 482
      PHA02664; hypothetical protein; Provisional
      pfam15045
      Location:555 → 624
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

    2. XM_005160173.5 → XP_005160230.1  aftiphilin a isoform X3

      UniProtKB/TrEMBL
      A0A8M2B7D9
      Conserved Domains (2) summary
      PHA02664
      Location:366 → 482
      PHA02664; hypothetical protein; Provisional
      pfam15045
      Location:555 → 624
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

    3. XM_005160174.5 → XP_005160231.1  aftiphilin a isoform X4

      UniProtKB/TrEMBL
      A0A8M2B721
      Conserved Domains (2) summary
      PHA02664
      Location:366 → 482
      PHA02664; hypothetical protein; Provisional
      pfam15045
      Location:555 → 624
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

    4. XM_005160171.5 → XP_005160228.1  aftiphilin a isoform X1

      See identical proteins and their annotated locations for XP_005160228.1

      UniProtKB/TrEMBL
      A0A8M1NRF7, B8JLD1
      Conserved Domains (2) summary
      PHA02664
      Location:366 → 482
      PHA02664; hypothetical protein; Provisional
      pfam15045
      Location:555 → 624
      Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
    Nucleotide Protein
    Heading Accession and Version

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