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    clpxa caseinolytic mitochondrial matrix peptidase chaperone subunit Xa [ Danio rerio (zebrafish) ]

    Gene ID: 447842, updated on 2-Nov-2024

    Summary

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    Official Symbol
    clpxaprovided by ZNC
    Official Full Name
    caseinolytic mitochondrial matrix peptidase chaperone subunit Xaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040912-143
    See related
    Ensembl:ENSDARG00000029063 AllianceGenome:ZFIN:ZDB-GENE-040912-143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    clpx; fb93b07; zgc:92303; wu:fb93b07
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Acts upstream of or within erythrocyte development. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in erythropoietic protoporphyria. Orthologous to human CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit X). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See clpxa in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (13639543..13678708)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (13422417..13444542, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family O member 2 Neighboring gene ankyrin repeat and death domain containing 1A Neighboring gene SPG21 abhydrolase domain containing, maspardin Neighboring gene programmed cell death 7 Neighboring gene ubiquitin associated protein 1-like b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria. Yien YY, et al. Proc Natl Acad Sci U S A, 2017 Sep 19. PMID 28874591, Free PMC Article
    2. Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis. Kardon JR, et al. Cell, 2015 May 7. PMID 25957689, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    caseinolytic mitochondrial matrix peptidase chaperone subunit Xa
    Names
    ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
    ClpX caseinolytic peptidase X homolog a
    caseinolytic mitochondrial matrix peptidase chaperone subunit a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004581.1 → NP_001004581.1  caseinolytic mitochondrial matrix peptidase chaperone subunit Xa

      See identical proteins and their annotated locations for NP_001004581.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081643
      UniProtKB/TrEMBL
      A0A8M1N258, F1QS10, Q66HW5
      Related
      ENSDARP00000029891.8, ENSDART00000032899.9
      Conserved Domains (4) summary
      smart01086
      Location:486 → 557
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
      TIGR00382
      Location:91 → 557
      clpX; endopeptidase Clp ATP-binding regulatory subunit (clpX)
      pfam07724
      Location:262 → 479
      AAA_2; AAA domain (Cdc48 subfamily)
      cl02609
      Location:93 → 121
      Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      13639543..13678708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477471.2 → XP_021333146.1  caseinolytic mitochondrial matrix peptidase chaperone subunit Xa isoform X1

      UniProtKB/TrEMBL
      A0A8M9QBU1
      Related
      ENSDARP00000132450.2, ENSDART00000157870.2
      Conserved Domains (2) summary
      PRK05342
      Location:161 → 599
      clpX; ATP-dependent protease ATP-binding subunit ClpX; Provisional
      cl02609
      Location:93 → 121
      Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit
    Nucleotide Protein Strain
    Heading Accession and Version

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