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    dennd2b DENN domain containing 2B [ Danio rerio (zebrafish) ]

    Gene ID: 323827, updated on 17-Aug-2024

    Summary

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    Official Symbol
    dennd2bprovided by ZNC
    Official Full Name
    DENN domain containing 2Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2547
    See related
    Ensembl:ENSDARG00000037363 AllianceGenome:ZFIN:ZDB-GENE-030131-2547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    st5; zgc:91902; wu:fc11b09; si:ch211-208c6.1
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of ERK1 and ERK2 cascade. Orthologous to human DENND2B (DENN domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See dennd2b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (28464980..28558651, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (28193600..28287318, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene RERG/RAS-like b Neighboring gene tripartite motif containing 66 Neighboring gene TMEM9 domain family, member B Neighboring gene signal peptide, CUB domain, EGF-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Kawakami A, et al. Curr Biol, 2005 Mar 8. PMID 15753045
    2. Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Liu C, et al. Sci Rep, 2015 Jan 29. PMID 25630924, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    suppression of tumorigenicity 5 protein
    Names
    suppression of tumorigenicity 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002327.1 → NP_001002327.1  suppression of tumorigenicity 5 protein

      See identical proteins and their annotated locations for NP_001002327.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076471
      UniProtKB/TrEMBL
      Q6DG80
      Related
      ENSDARP00000100317.1, ENSDART00000113313.3
      Conserved Domains (3) summary
      smart00801
      Location:1011 → 1077
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:683 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:778 → 962
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      28464980..28558651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166388.4 → XP_005166445.1  suppression of tumorigenicity 5 protein isoform X1

      UniProtKB/TrEMBL
      A0A8M2BDS4, Q5RHZ1
      Conserved Domains (3) summary
      smart00801
      Location:1011 → 1077
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:683 → 771
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:778 → 962
      DENN; DENN (AEX-3) domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394693.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      166506..222430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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