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    arfip2a ADP-ribosylation factor interacting protein 2a [ Danio rerio (zebrafish) ]

    Gene ID: 449664, updated on 2-Nov-2024

    Summary

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    Official Symbol
    arfip2aprovided by ZNC
    Official Full Name
    ADP-ribosylation factor interacting protein 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-221
    See related
    Ensembl:ENSDARG00000059244 AllianceGenome:ZFIN:ZDB-GENE-041010-221
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj35g06; zgc:92579; wu:fj35g06
    Summary
    Predicted to enable phospholipid binding activity. Predicted to be involved in intracellular protein transport and regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be active in trans-Golgi network membrane. Is expressed in nervous system; neural tube; notochord; polster; and trigeminal placode. Orthologous to human ARFIP2 (ADP ribosylation factor interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See arfip2a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (32249071..32267158)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (32391075..32409174)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene BRCA2 DNA repair associated Neighboring gene uncharacterized LOC137487768 Neighboring gene dachsous cadherin-related 1a Neighboring gene FH2 domain containing 4 Neighboring gene tripartite motif containing 3a Neighboring gene complement component 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Highly divergent gene expression programs can lead to similar chordate larval body plans. Sobral D, et al. Curr Biol, 2009 Dec 15. PMID 19931456
    2. Genomic organization and evolution of olfactory receptors and trace amine-associated receptors in channel catfish, Ictalurus punctatus. Gao S, et al. Biochim Biophys Acta Gen Subj, 2017 Mar. PMID 27773705
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arfaptin-2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005935.1 → NP_001005935.1  arfaptin-2a

      See identical proteins and their annotated locations for NP_001005935.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083521
      UniProtKB/TrEMBL
      A0A8M1N2K5, Q5XIZ7
      Related
      ENSDARP00000076751.3, ENSDART00000082315.5
      Conserved Domains (1) summary
      cd07660
      Location:173 → 373
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      32249071..32267158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157358.5 → XP_005157415.1  arfaptin-2a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B475
      Conserved Domains (1) summary
      cd07660
      Location:192 → 392
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    2. XM_005157359.5 → XP_005157416.1  arfaptin-2a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B452
      Conserved Domains (1) summary
      cd07660
      Location:171 → 371
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    3. XM_005157361.5 → XP_005157418.1  arfaptin-2a isoform X4

      UniProtKB/TrEMBL
      A0A8M2B3H5
      Conserved Domains (1) summary
      cd07660
      Location:144 → 344
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    4. XM_005157360.5 → XP_005157417.1  arfaptin-2a isoform X3

      UniProtKB/TrEMBL
      A0A8M2B3G2, F1QJ24
      Related
      ENSDARP00000123682.2, ENSDART00000133867.4
      Conserved Domains (1) summary
      cd07660
      Location:152 → 352
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    5. XM_005157362.5 → XP_005157419.1  arfaptin-2a isoform X5

      UniProtKB/TrEMBL
      A0A8M2B3N8
      Conserved Domains (1) summary
      cd07660
      Location:125 → 325
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    Nucleotide Protein
    Heading Accession and Version

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