retsat.2 retinol saturase, tandem duplicate 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: retsat.2provided by ZNC
Official Full Name: retinol saturase, tandem duplicate 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-11
See related: Ensembl:ENSDARG00000018600 AllianceGenome:ZFIN:ZDB-GENE-050320-11
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: retsat; RetSat A; wu:fd46d06; zgc:113107
Summary: Enables all-trans-retinol 13,14-reductase activity. Acts upstream of or within retinol metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in gut and liver. Orthologous to human RETSAT (retinol saturase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (39181392..39190264, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (39039534..39048406, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

reported the identification of two putative RetSat homologues in zebrafish, one of which, zebrafish RetSat A (zRetSat A), also had retinol saturase activity, whereas zebrafish RetSat B (zRetSat B) was inactive under similar conditions
Title: Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables all-trans-retinol 13,14-reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol 13,14-reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables all-trans-retinol 13,14-reductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinol metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: all-trans-retinol 13,14-reductase

Names: all-trans-13,14-dihydroretinol saturase A; all-trans-retinol 7,8-reductase; putative all-trans-retinol 13,14-reductase; retinol saturase (all-trans-retinol 13,14-reductase); zRetSat A

NP_001015061.1

EC 1.3.99.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015061.2 → NP_001015061.1 all-trans-retinol 13,14-reductase precursor

See identical proteins and their annotated locations for NP_001015061.1

Status: PROVISIONAL

Source sequence(s)

BC090469

UniProtKB/Swiss-Prot

Q5BLE8, Q6DBT4

Related

ENSDARP00000024120.7, ENSDART00000013167.8

Conserved Domains (3) summary

COG0446
Location:15 → 99

FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

COG1233
Location:61 → 562

COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]

cl21454
Location:64 → 570

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins