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    sod2 superoxide dismutase 2, mitochondrial [ Danio rerio (zebrafish) ]

    Gene ID: 335799, updated on 28-Oct-2024

    Summary

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    Official Symbol
    sod2provided by ZNC
    Official Full Name
    superoxide dismutase 2, mitochondrialprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7742
    See related
    Ensembl:ENSDARG00000042644 AllianceGenome:ZFIN:ZDB-GENE-030131-7742
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb463; zgc:73051; wu:fj33b01
    Summary
    Enables superoxide dismutase activity. Acts upstream of or within several processes, including neutrophil homeostasis; removal of superoxide radicals; and response to methylmercury. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; hematopoietic cell; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sod2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (30939178..30947547)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (31036299..31044668)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene acetyl-CoA acetyltransferase 2 Neighboring gene WT1 associated protein Neighboring gene fibronectin type III domain containing 1 Neighboring gene ciliary microtubule inner protein 2C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization, molecular modelling and developmental expression of zebrafish manganese superoxide dismutase. Lin CT, et al. Fish Shellfish Immunol, 2009 Aug. PMID 19501168
    2. Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish. Zhang M, et al. PLoS One, 2015. PMID 26186000, Free PMC Article
    3. Neutralization of mitochondrial superoxide by superoxide dismutase 2 promotes bacterial clearance and regulates phagocyte numbers in zebrafish. Peterman EM, et al. Infect Immun, 2015 Jan. PMID 25385799, Free PMC Article
    4. Primary structure and properties of Mn-superoxide dismutase from scallop adductor muscle. Ikebuchi M, et al. Int J Biochem Cell Biol, 2006. PMID 16324874
    5. Cypermethrin: Oxidative stress and genotoxicity in retinal cells of the adult zebrafish. Paravani EV, et al. Mutat Res Genet Toxicol Environ Mutagen, 2018 Feb. PMID 29412866

    See all (253) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide dismutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables superoxide dismutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables superoxide dismutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neutrophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within removal of superoxide radicals IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to methylmercury IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    superoxide dismutase [Mn], mitochondrial
    Names
    Mn-SOD
    manganese superoxide dismutase
    sod(Mn)
    NP_956270.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199976.1 → NP_956270.1  superoxide dismutase [Mn], mitochondrial

      See identical proteins and their annotated locations for NP_956270.1

      Status: PROVISIONAL

      Source sequence(s)
      BC060895
      UniProtKB/TrEMBL
      A0A8M1PC95, Q6P980
      Related
      ENSDARP00000062555.3, ENSDART00000062556.4
      Conserved Domains (3) summary
      COG0605
      Location:25 → 224
      SodA; Superoxide dismutase [Inorganic ion transport and metabolism]
      pfam00081
      Location:27 → 108
      Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
      pfam02777
      Location:115 → 218
      Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      30939178..30947547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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