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    cd74b CD74 molecule, major histocompatibility complex, class II invariant chain b [ Danio rerio (zebrafish) ]

    Gene ID: 30645, updated on 28-Oct-2024

    Summary

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    Official Symbol
    cd74bprovided by ZNC
    Official Full Name
    CD74 molecule, major histocompatibility complex, class II invariant chain bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990910-10
    See related
    Ensembl:ENSDARG00000036628 AllianceGenome:ZFIN:ZDB-GENE-990910-10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cd74; iclp2; Iclp-2; zgc:123161
    Summary
    Predicted to enable MHC class II protein binding activity; cytokine receptor activity; and macrophage migration inhibitory factor binding activity. Acts upstream of or within inner ear development and neuromast development. Predicted to be located in extracellular region and membrane. Predicted to be active in cell surface and cytoplasm. Is expressed in inner ear and otic vesicle. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cd74b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (33459562..33463893)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (33424063..33429514)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1b Neighboring gene uncharacterized LOC137488835 Neighboring gene SLC35A4 upstream open reading frame protein-like Neighboring gene ribosomal protein S14 Neighboring gene clathrin interactor 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules. Dijkstra JM, et al. Immunogenetics, 2019 Mar. PMID 30377750
    2. The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio. Shen YC, et al. Dev Biol, 2012 Mar 1. PMID 22210003, Free PMC Article
    3. High-fat diet impairs cognitive function of zebrafish. Meguro S, et al. Sci Rep, 2019 Nov 19. PMID 31745184, Free PMC Article
    4. Zebrafish Model for Functional Screening of Flow-Responsive Genes. Serbanovic-Canic J, et al. Arterioscler Thromb Vasc Biol, 2017 Jan. PMID 27834691, Free PMC Article
    5. Early embryonic gene expression profiling of zebrafish prion protein (Prp2) morphants. Nourizadeh-Lillabadi R, et al. PLoS One, 2010 Oct 22. PMID 21042590, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123161, MGC158500

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables MHC class II protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MHC class II protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables macrophage migration inhibitory factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables macrophage migration inhibitory factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inner ear development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuromast development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of macrophage cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of type 2 immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CD74 molecule, major histocompatibility complex, class II invariant chain b
    Names
    invariant chain-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131372.2 → NP_571447.1  CD74 molecule, major histocompatibility complex, class II invariant chain b

      See identical proteins and their annotated locations for NP_571447.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127569
      UniProtKB/TrEMBL
      A1L140, Q9PVD9
      Related
      ENSDARP00000053204.4, ENSDART00000053205.6
      Conserved Domains (2) summary
      cd00191
      Location:121 → 179
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam09307
      Location:10 → 100
      MHC2-interact; CLIP, MHC2 interacting

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      33459562..33463893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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