U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    gjc4a.1 gap junction protein gamma 4a.1 [ Danio rerio (zebrafish) ]

    Gene ID: 114404, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    gjc4a.1provided by ZNC
    Official Full Name
    gap junction protein gamma 4a.1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010619-1
    See related
    Ensembl:ENSDARG00000034207 AllianceGenome:ZFIN:ZDB-GENE-010619-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gjc4a; cx44.2; fk18g12; wu:fk18g12; etID18867.6
    Summary
    Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling. Predicted to act upstream of or within cell communication. Predicted to be located in gap junction and plasma membrane. Predicted to be part of connexin complex. Is expressed in Kupffer's vesicle; ovary; and testis. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See gjc4a.1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (21001455..21009814)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (18941233..18949540)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 2a Neighboring gene serine/threonine kinase 11 interacting protein Neighboring gene si:dkey-91f15.8 Neighboring gene gap junction protein gamma 4a.2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A gap junction connexin is required in the vertebrate left-right organizer. Hatler JM, et al. Dev Biol, 2009 Dec 15. PMID 19799895
    2. Molecular basis of sex and reproductive status in breeding zebrafish. Santos EM, et al. Physiol Genomics, 2007 Jul 18. PMID 17374843
    3. A genome-wide map of circular RNAs in adult zebrafish. Sharma D, et al. Sci Rep, 2019 Mar 5. PMID 30837568, Free PMC Article
    4. Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies. Mikalsen SO, et al. BMC Genomics, 2020 Mar 11. PMID 32160866, Free PMC Article
    5. Evolutionary selection pressure and family relationships among connexin genes. Cruciani V, et al. Biol Chem, 2007 Mar. PMID 17338632

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of connexin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of connexin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    gap junction protein gamma 4a.1
    Names
    connexin 44.2
    gap junction protein gamma 4a

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131810.2 → NP_571885.2  gap junction protein gamma 4a.1

      See identical proteins and their annotated locations for NP_571885.2

      Status: PROVISIONAL

      Source sequence(s)
      BC045279
      UniProtKB/TrEMBL
      Q7ZU26
      Related
      ENSDARP00000044518.5, ENSDART00000044519.6
      Conserved Domains (3) summary
      smart00037
      Location:43 → 75
      CNX; Connexin homologues
      smart01089
      Location:193 → 259
      Connexin_CCC; Gap junction channel protein cysteine-rich domain
      pfam00029
      Location:2 → 261
      Connexin; Connexin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      21001455..21009814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476749.2 → XP_021332424.1  gap junction protein gamma 4a.1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q5X3, F1QYI2
      Conserved Domains (1) summary
      pfam00029
      Location:2 → 261
      Connexin; Connexin

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394633.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      234595..242655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools