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    kif23 kinesin family member 23 [ Danio rerio (zebrafish) ]

    Gene ID: 30627, updated on 2-Nov-2024

    Summary

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    Official Symbol
    kif23provided by ZNC
    Official Full Name
    kinesin family member 23provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991019-4
    See related
    Ensembl:ENSDARG00000014943 AllianceGenome:ZFIN:ZDB-GENE-991019-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb738; knsl5; mklp1; zMKLP1; wu:fi30e02; wu:fi39f08
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within cytoskeleton-dependent cytokinesis; embryonic cleavage; and vesicle transport along microtubule. Located in several cellular components, including cleavage furrow; microtubule; and nucleus. Is expressed in proliferative region. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type III. Orthologous to human KIF23 (kinesin family member 23). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kif23 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (20436274..20458369, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (20447208..20469362, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uveal autoantigen with coiled-coil domains and ankyrin repeats a Neighboring gene TLE family member 3, transcriptional corepressor a Neighboring gene progestin and adipoQ receptor family member Va Neighboring gene damage-specific DNA binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Multiple roles of the furrow deepening Ca2+ transient during cytokinesis in zebrafish embryos. Li WM, et al. Dev Biol, 2008 Apr 15. PMID 18313658
    2. Zebrafish mitotic kinesin-like protein 1 (Mklp1) functions in embryonic cytokinesis. Chen MC, et al. Physiol Genomics, 2002 Feb 11. PMID 11842131
    3. Reversible neuronal and muscular toxicity of caffeine in developing vertebrates. Rodriguez RS, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2014 Jun. PMID 24667760
    4. Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish. González-Rosa JM, et al. Dev Cell, 2018 Feb 26. PMID 29486195, Free PMC Article
    5. PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. Gulluni F, et al. Science, 2021 Dec 10. PMID 34882480, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109838, MGC192860

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cleavage furrow formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like protein KIF23
    Names
    kinesin-like 5
    mitotic kinesin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131355.1 → NP_571430.1  kinesin-like protein KIF23

      See identical proteins and their annotated locations for NP_571430.1

      Status: PROVISIONAL

      Source sequence(s)
      AF139990
      UniProtKB/TrEMBL
      A0A0R4IKS5, A0A8N7UZJ3, Q9PUU5
      Related
      ENSDARP00000026695.8, ENSDART00000012241.10
      Conserved Domains (6) summary
      cd01368
      Location:24 → 434
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31 → 436
      Kinesin; Kinesin motor domain
      pfam08614
      Location:453 → 633
      ATG16; Autophagy protein 16 (ATG16)
      pfam16046
      Location:535 → 596
      FAM76; FAM76 protein
      pfam16540
      Location:710 → 810
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl23720
      Location:505 → 657
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      20436274..20458369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467587.2 → XP_021323262.1  kinesin-like protein KIF23 isoform X2

      UniProtKB/TrEMBL
      A0A8M9P0Y6
      Conserved Domains (3) summary
      cd01368
      Location:24 → 434
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:810 → 913
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl25732
      Location:511 → 684
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_009293529.4 → XP_009291804.1  kinesin-like protein KIF23 isoform X3

      UniProtKB/TrEMBL
      A0A286Y967, A0A8M3AUT8
      Related
      ENSDARP00000143716.1, ENSDART00000177125.2
      Conserved Domains (6) summary
      cd01368
      Location:24 → 449
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31 → 451
      Kinesin; Kinesin motor domain
      pfam08614
      Location:468 → 648
      ATG16; Autophagy protein 16 (ATG16)
      pfam16046
      Location:550 → 611
      FAM76; FAM76 protein
      pfam16540
      Location:725 → 825
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl23720
      Location:520 → 672
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. XM_021467586.2 → XP_021323261.1  kinesin-like protein KIF23 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PLX5
      Conserved Domains (3) summary
      cd01368
      Location:24 → 449
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:825 → 928
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl25732
      Location:526 → 699
      SMC_N; RecF/RecN/SMC N terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395022.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      29838..51882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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