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    zdhhc2 zinc finger DHHC-type palmitoyltransferase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 541365, updated on 28-Oct-2024

    Summary

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    Official Symbol
    zdhhc2provided by ZNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-58
    See related
    Ensembl:ENSDARG00000034757 AllianceGenome:ZFIN:ZDB-GENE-050320-58
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fk53a02; zgc:110777
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation; protein targeting to membrane; and synapse assembly. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; postsynaptic density; and postsynaptic recycling endosome. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See zdhhc2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (30426956..30452234, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (30086642..30111796, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 7a Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene mitochondrial calcium uptake family, member 3b Neighboring gene fibroblast growth factor 20b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Wang C, et al. Neurotoxicol Teratol, 2015 Jul-Aug. PMID 26056731
    2. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-stearoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC2
    Names
    DHHC domain-containing protein 2
    acyltransferase ZDHHC2
    zinc finger DHHC domain-containing protein 2
    zinc finger, DHHC-type containing 2
    NP_001013510.1
    XP_021336686.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013492.1 → NP_001013510.1  palmitoyltransferase ZDHHC2

      See identical proteins and their annotated locations for NP_001013510.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090450
      UniProtKB/Swiss-Prot
      Q5BLG4
      Related
      ENSDARP00000019867.5, ENSDART00000011480.8
      Conserved Domains (1) summary
      cl19890
      Location:11 → 292
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      30426956..30452234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481011.2 → XP_021336686.1  palmitoyltransferase ZDHHC2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QKK4
      Conserved Domains (1) summary
      cl19890
      Location:11 → 305
      zf-DHHC; DHHC palmitoyltransferase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394914.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      357099..381944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BLG4.1 GenPept UniProtKB/Swiss-Prot:Q5BLG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.