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    PSRC1 proline and serine rich coiled-coil 1 [ Homo sapiens (human) ]

    Gene ID: 84722, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PSRC1provided by HGNC
    Official Full Name
    proline and serine rich coiled-coil 1provided by HGNC
    Primary source
    HGNC:HGNC:24472
    See related
    Ensembl:ENSG00000134222 MIM:613126; AllianceGenome:HGNC:24472
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DDA3; FP3214
    Summary
    This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]
    Expression
    Broad expression in brain (RPKM 9.0), testis (RPKM 4.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PSRC1 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109279556..109283145, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109312356..109315945, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (109822178..109825767, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1437 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:109767996-109768680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109768681-109769365 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109772336-109773132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109773133-109773930 Neighboring gene seryl-tRNA synthetase 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:109779623-109780822 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:109781947-109782361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109782763-109783458 Neighboring gene Sharpr-MPRA regulatory region 12007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109785117-109785616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109791478-109792198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1145 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:109793618-109793808 Neighboring gene VISTA enhancer hs2216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109802367-109802915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109803429-109803928 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109806365-109807347 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:109807766-109807952 Neighboring gene cadherin EGF LAG seven-pass G-type receptor 2 Neighboring gene VISTA enhancer hs2263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109820047-109820796 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109826136-109826861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109839316-109839887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109842955-109843465 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:109843466-109843975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109849151-109849890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:109849891-109850629 Neighboring gene myosin binding protein H like Neighboring gene MPRA-validated peak354 silencer Neighboring gene sortilin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1149

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Association of single nucleotide polymorphism rs599839 on chromosome 1p13.3 with premature coronary heart disease in a Chinese Han population]. Huang H, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2008 Dec. PMID 19065533
    2. Phospho-regulation of DDA3 function in mitosis. Jang CY, et al. Biochem Biophys Res Commun, 2010 Mar 5. PMID 20117088, Free PMC Article
    3. Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease. Linsel-Nitschke P, et al. Atherosclerosis, 2010 Jan. PMID 19660754
    4. DDA3: a new dancer at the growing end? Zhang L, et al. Cell Cycle, 2010 Jan 15. PMID 20061788
    5. Multivariate analysis for coronary heart disease in heterozygote familial hypercholesterolemia patients. Sánchez Muñoz-Torrero JF, et al. Per Med, 2018 Mar. PMID 29714125

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetically programmed changes in transcription of the novel progranulin regulator.
      Title: Genetically programmed changes in transcription of the novel progranulin regulator.
    2. Association of the PSRC1 rs599839 Variant with Coronary Artery Disease in a Mexican Population.
      Title: Association of the PSRC1 rs599839 Variant with Coronary Artery Disease in a Mexican Population.
    3. Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length.
      Title: Reciprocal regulation of Aurora kinase A and ATIP3 in the control of metaphase spindle length.
    4. the frequency of SNP rs599839 located in the 3' UTR of the PSRC1 gene in patients with genetically confirmed diagnosis of heterozygous familial hypercholesterolemia was analyzed. It was found that there was no association between rs599839 alleles and coronary heart disease in the multivariate analysis.
      Title: Multivariate analysis for coronary heart disease in heterozygote familial hypercholesterolemia patients.
    5. Mdp3 (also known as MAP7D3) forms a complex with DDA3 (also known as PSRC1) and controls spindle dynamics at the minus end of Microtubuless by inhibiting DDA3-mediated Kif2a recruitment to the spindle.
      Title: DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics.
    6. these data indicate that ASB7 plays a crucial role in regulating spindle dynamics and genome integrity by controlling the expression of DDA3.
      Title: ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.
    7. no association was found between the SNPs of rs599839, rs464218 and rs6698843 at the CELSR2-PSRC1-SORT1 and the risk of coronary artery disease or ischemic stroke
      Title: Association of variants in CELSR2-PSRC1-SORT1 with risk of serum lipid traits, coronary artery disease and ischemic stroke.
    8. Thus, ANKRD53 is recruited to the mitotic spindle by DDA3 and acts as a regulator of spindle dynamics and cytokinesis.
      Title: ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis.
    9. Thus, our findings identified a definite regulatory mechanism of the search and capture process for stable spindle attachment through cross-talk between spindle dynamics and KT composition mediated by DDA3 and Ska1.
      Title: Ska1 cooperates with DDA3 for spindle dynamics and spindle attachment to kinetochore.
    10. DDA3 controls astral spindle formation and spindle positioning by targeting Cep290 to the centrosome. Depletion of Cep290 caused a reduction of the astral spindle, leading to misorientation of the mitotic spindle.
      Title: DDA3 targets Cep290 into the centrosome to regulate spindle positioning.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
    EBI GWAS Catalog
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Common variants at 30 loci contribute to polygenic dyslipidemia.
    EBI GWAS Catalog
    Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
    EBI GWAS Catalog
    Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
    EBI GWAS Catalog
    Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
    EBI GWAS Catalog
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    EBI GWAS Catalog
    Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
    EBI GWAS Catalog
    Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
    EBI GWAS Catalog
    Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.
    EBI GWAS Catalog
    Genomewide association analysis of coronary artery disease.
    EBI GWAS Catalog
    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
    EBI GWAS Catalog
    Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
    EBI GWAS Catalog
    LDL-cholesterol concentrations: a genome-wide association study.
    EBI GWAS Catalog
    Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
    EBI GWAS Catalog
    Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
    EBI GWAS Catalog
    Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC1780

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of mitotic spindle organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    colocalizes_with spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proline/serine-rich coiled-coil protein 1
    Names
    differential display and activated by p53
    p53-regulated DDA3
    proline/serine-rich coiled-coil 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005290.4 → NP_001005290.1  proline/serine-rich coiled-coil protein 1 isoform b

      See identical proteins and their annotated locations for NP_001005290.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses two different alternate splice sites, which results in a frameshift, compared to variant 1. It encodes isoform b which has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BJ992594, BX649139
      Consensus CDS
      CCDS30791.1
      UniProtKB/Swiss-Prot
      Q6PGN9
      Related
      ENSP00000358920.3, ENST00000369904.7
      Conserved Domains (1) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    2. NM_001032291.3 → NP_001027462.1  proline/serine-rich coiled-coil protein 1 isoform a

      See identical proteins and their annotated locations for NP_001027462.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
      Source sequence(s)
      AK289593, AL390252, BI857497, BJ992594
      Consensus CDS
      CCDS797.1
      UniProtKB/TrEMBL
      A8K0M8
      Related
      ENSP00000358925.2, ENST00000369909.7
      Conserved Domains (2) summary
      PRK07003
      Location:98 → 333
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    3. NM_001350237.2 → NP_001337166.1  proline/serine-rich coiled-coil protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
      Source sequence(s)
      AL390252, AW898470, BX649139, DA141210, DA666480
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (2) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1
      cl26464
      Location:47 → 317
      Atrophin-1; Atrophin-1 family

    4. NM_001350238.2 → NP_001337167.1  proline/serine-rich coiled-coil protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
      Source sequence(s)
      AW898470, BJ992594, BX649139, DR158928
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (2) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1
      cl26464
      Location:47 → 317
      Atrophin-1; Atrophin-1 family

    5. NM_001350239.2 → NP_001337168.1  proline/serine-rich coiled-coil protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
      Source sequence(s)
      AW898470, BJ992594, BX649139, DR158928
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (2) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1
      cl26464
      Location:47 → 317
      Atrophin-1; Atrophin-1 family

    6. NM_001350240.2 → NP_001337169.1  proline/serine-rich coiled-coil protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
      Source sequence(s)
      AW898470, BP354477, BX649139, DR158928
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (2) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1
      cl26464
      Location:47 → 317
      Atrophin-1; Atrophin-1 family

    7. NM_001350241.2 → NP_001337170.1  proline/serine-rich coiled-coil protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
      Source sequence(s)
      AW898470, BJ992594, BX649139, CN405809
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (2) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1
      cl26464
      Location:47 → 317
      Atrophin-1; Atrophin-1 family

    8. NM_001350242.2 → NP_001337171.1  proline/serine-rich coiled-coil protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and uses two alternate splice sites in the central coding region, but maintains the reading frame, compared to variant 1. It encodes isoform d which has the same N- and C-termini, but is shorter than isoform a. Variant 5-10 encode the same isoform (d).
      Source sequence(s)
      AW898470, BG281896, BJ992594, BX649139
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (2) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1
      cl26464
      Location:47 → 317
      Atrophin-1; Atrophin-1 family

    9. NM_001363309.2 → NP_001350238.1  proline/serine-rich coiled-coil protein 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and retains an intron in the 3' coding region compared to variant 1. It encodes isoform c which has the same N- and C-termini, as well as an additional segment, compared to isoform a
      Source sequence(s)
      BC056909, BI857497
      Consensus CDS
      CCDS30792.1
      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
      UniProtKB/TrEMBL
      A8K0M8
      Related
      ENSP00000474667.1, ENST00000409138.6
      Conserved Domains (1) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    10. NM_001394002.1 → NP_001380931.1  proline/serine-rich coiled-coil protein 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL390252, KF459601
      Consensus CDS
      CCDS797.1
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (2) summary
      PRK07003
      Location:98 → 333
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    11. NM_001394003.1 → NP_001380932.1  proline/serine-rich coiled-coil protein 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL390252, KF459601
      Consensus CDS
      CCDS30791.1
      Conserved Domains (1) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    12. NM_001394004.1 → NP_001380933.1  proline/serine-rich coiled-coil protein 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL390252, KF459601
      Consensus CDS
      CCDS30791.1
      Conserved Domains (1) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    13. NM_001394005.1 → NP_001380934.1  proline/serine-rich coiled-coil protein 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL390252, KF459601
      Consensus CDS
      CCDS30792.1
      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (1) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    14. NM_032636.8 → NP_116025.1  proline/serine-rich coiled-coil protein 1 isoform a

      See identical proteins and their annotated locations for NP_116025.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the second-longest isoform (a). Both variants 1 and 3 encode the same isoform (a).
      Source sequence(s)
      AF223000, BI857497
      Consensus CDS
      CCDS797.1
      UniProtKB/TrEMBL
      A8K0M8
      Related
      ENSP00000358923.3, ENST00000369907.7
      Conserved Domains (2) summary
      PRK07003
      Location:98 → 333
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      109279556..109283145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271283.4 → XP_005271340.1  proline/serine-rich coiled-coil protein 1 isoform X2

      See identical proteins and their annotated locations for XP_005271340.1

      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (2) summary
      PRK07003
      Location:98 → 333
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    2. XM_047432284.1 → XP_047288240.1  proline/serine-rich coiled-coil protein 1 isoform X4

    3. XM_047432275.1 → XP_047288231.1  proline/serine-rich coiled-coil protein 1 isoform X3

    4. XM_047432277.1 → XP_047288233.1  proline/serine-rich coiled-coil protein 1 isoform X4

    5. XM_017002564.2 → XP_016858053.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (1) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    6. XM_017002569.2 → XP_016858058.1  proline/serine-rich coiled-coil protein 1 isoform X2

      UniProtKB/TrEMBL
      A8K0M8
      Related
      ENSP00000358919.2, ENST00000369903.6
      Conserved Domains (2) summary
      PRK07003
      Location:98 → 333
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    7. XM_047432274.1 → XP_047288230.1  proline/serine-rich coiled-coil protein 1 isoform X3

    8. XM_047432251.1 → XP_047288207.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

    9. XM_017002560.3 → XP_016858049.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (1) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    10. XM_047432255.1 → XP_047288211.1  proline/serine-rich coiled-coil protein 1 isoform X2

    11. XM_017002562.2 → XP_016858051.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (1) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    12. XM_047432272.1 → XP_047288228.1  proline/serine-rich coiled-coil protein 1 isoform X2

      Related
      ENSP00000386323.1, ENST00000409267.5

    13. XM_017002567.2 → XP_016858056.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (1) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    14. XM_017002570.2 → XP_016858059.1  proline/serine-rich coiled-coil protein 1 isoform X2

      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (2) summary
      PRK07003
      Location:98 → 333
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    15. XM_047432294.1 → XP_047288250.1  proline/serine-rich coiled-coil protein 1 isoform X4

    16. XM_017002566.2 → XP_016858055.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (1) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    17. XM_047432264.1 → XP_047288220.1  proline/serine-rich coiled-coil protein 1 isoform X2

    18. XM_017002563.2 → XP_016858052.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77
      UniProtKB/TrEMBL
      A8K0M8
      Conserved Domains (1) summary
      pfam15259
      Location:8 → 122
      GTSE1_N; G-2 and S-phase expressed 1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      109312356..109315945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339232.1 → XP_054195207.1  proline/serine-rich coiled-coil protein 1 isoform X2

    2. XM_054339238.1 → XP_054195213.1  proline/serine-rich coiled-coil protein 1 isoform X4

    3. XM_054339236.1 → XP_054195211.1  proline/serine-rich coiled-coil protein 1 isoform X3

    4. XM_054339237.1 → XP_054195212.1  proline/serine-rich coiled-coil protein 1 isoform X4

    5. XM_054339223.1 → XP_054195198.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

    6. XM_054339230.1 → XP_054195205.1  proline/serine-rich coiled-coil protein 1 isoform X2

    7. XM_054339235.1 → XP_054195210.1  proline/serine-rich coiled-coil protein 1 isoform X3

    8. XM_054339228.1 → XP_054195203.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

    9. XM_054339222.1 → XP_054195197.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

    10. XM_054339229.1 → XP_054195204.1  proline/serine-rich coiled-coil protein 1 isoform X2

    11. XM_054339224.1 → XP_054195199.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

    12. XM_054339234.1 → XP_054195209.1  proline/serine-rich coiled-coil protein 1 isoform X2

    13. XM_054339227.1 → XP_054195202.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

    14. XM_054339233.1 → XP_054195208.1  proline/serine-rich coiled-coil protein 1 isoform X2

    15. XM_054339239.1 → XP_054195214.1  proline/serine-rich coiled-coil protein 1 isoform X4

    16. XM_054339225.1 → XP_054195200.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

    17. XM_054339231.1 → XP_054195206.1  proline/serine-rich coiled-coil protein 1 isoform X2

    18. XM_054339226.1 → XP_054195201.1  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5T2Z3, Q6PGN9, Q6ZTI8, Q71MG3, Q9BV77

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001032290.1: Suppressed sequence

      Description
      NM_001032290.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PGN9.1 GenPept UniProtKB/Swiss-Prot:Q6PGN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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