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    NCAPG2 non-SMC condensin II complex subunit G2 [ Homo sapiens (human) ]

    Gene ID: 54892, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NCAPG2provided by HGNC
    Official Full Name
    non-SMC condensin II complex subunit G2provided by HGNC
    Primary source
    HGNC:HGNC:21904
    See related
    Ensembl:ENSG00000146918 MIM:608532; AllianceGenome:HGNC:21904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    3KS; MTB; CAPG2; LUZP5; CAP-G2; hCAP-G2
    Summary
    This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Broad expression in testis (RPKM 7.7), bone marrow (RPKM 6.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NCAPG2 in Genome Data Viewer
    Location:
    7q36.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (158631169..158704804, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (159858401..159932192, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (158423861..158497495, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158389617-158390116 Neighboring gene long intergenic non-protein coding RNA 1022 Neighboring gene microRNA 5707 Neighboring gene THAP domain containing 5 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158455355-158455856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158455857-158456356 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:158456637-158457836 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158496256-158496834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18868 Neighboring gene ribosomal protein L21 pseudogene 76 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:158526538-158527737 Neighboring gene extended synaptotagmin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158589571-158590070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158593246-158593746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158593747-158594247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158596845-158597436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158604138-158604712 Neighboring gene Sharpr-MPRA regulatory region 8416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26932 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18873

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways. Meng F, et al. EBioMedicine, 2019 Jun. PMID 31176678, Free PMC Article
    2. NCAPG2 contributes to the progression of malignant melanoma through regulating proliferation and metastasis. Feng Z, et al. Biochem Cell Biol, 2022 Dec 1. PMID 36265182
    3. NCAPG2 promotes tumour proliferation by regulating G2/M phase and associates with poor prognosis in lung adenocarcinoma. Zhan P, et al. J Cell Mol Med, 2017 Apr. PMID 27862966, Free PMC Article
    4. Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies. Khan TN, et al. Am J Hum Genet, 2019 Jan 3. PMID 30609410, Free PMC Article
    5. MYC and NCAPG2 as molecular targets of colorectal cancer and gastric cancer in nursing. Mi X, et al. Medicine (Baltimore), 2024 May 3. PMID 38701261, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MYC and NCAPG2 as molecular targets of colorectal cancer and gastric cancer in nursing.
      Title: MYC and NCAPG2 as molecular targets of colorectal cancer and gastric cancer in nursing.
    2. NCAPG2 promotes prostate cancer malignancy and stemness via STAT3/c-MYC signaling.
      Title: NCAPG2 promotes prostate cancer malignancy and stemness via STAT3/c-MYC signaling.
    3. The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.
      Title: The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.
    4. Circular RNA circ0001955 promotes cervical cancer tumorigenesis and metastasis via the miR-188-3p/NCAPG2 axis.
      Title: Circular RNA circ0001955 promotes cervical cancer tumorigenesis and metastasis via the miR-188-3p/NCAPG2 axis.
    5. NCAPG2 contributes to the progression of malignant melanoma through regulating proliferation and metastasis.
      Title: NCAPG2 contributes to the progression of malignant melanoma through regulating proliferation and metastasis.
    6. microRNA-375 inhibits the malignant behaviors of hepatic carcinoma cells by targeting NCAPG2.
      Title: microRNA-375 inhibits the malignant behaviors of hepatic carcinoma cells by targeting NCAPG2.
    7. NCAPG2 facilitates glioblastoma cells' malignancy and xenograft tumor growth via HBO1 activation by phosphorylation.
      Title: NCAPG2 facilitates glioblastoma cells' malignancy and xenograft tumor growth via HBO1 activation by phosphorylation.
    8. that NCAPG2 is an important oncogene that contributes to HCC proliferation and metastasis. NCAPG2 can activate both the STAT3 and NF-kappaB pathways and activated STAT3 positively regulates NCAPG2 expression.
      Title: NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways.
    9. data suggest that impaired function of NCAPG2 results in a severe condensinopathy, and they highlight the potential utility of examining candidate pathogenic lesions beyond the primary disease locus
      Title: Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies.
    10. increased NCAPG2 expression could regulate cell proliferation and identified as a poor prognostic biomarker in lung adenocarcinoma.
      Title: NCAPG2 promotes tumour proliferation by regulating G2/M phase and associates with poor prognosis in lung adenocarcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Khan-Khan-Katsanis syndrome
    MedGen: C5193110 OMIM: 618460 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ20311

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bHLH transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inner cell mass cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of chromosome condensation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    condensin-2 complex subunit G2
    Names
    chromosome-associated protein G2
    leucine zipper protein 5
    more than blood homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047159.1 RefSeqGene

      Range
      5028..78663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001281932.2 → NP_001268861.1  condensin-2 complex subunit G2 isoform a

      See identical proteins and their annotated locations for NP_001268861.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
      Source sequence(s)
      AC019084, AC093662, AK092008, DB069860, DW419642
      Consensus CDS
      CCDS43686.1
      UniProtKB/Swiss-Prot
      A4D228, Q7Z3J9, Q86XI2, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6
      UniProtKB/TrEMBL
      B3KRQ2
      Related
      ENSP00000386569.1, ENST00000409423.5
      Conserved Domains (2) summary
      pfam12422
      Location:213 → 361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368 → 405
      HEAT; HEAT repeat [structural motif]

    2. NM_001281933.2 → NP_001268862.1  condensin-2 complex subunit G2 isoform b

      See identical proteins and their annotated locations for NP_001268862.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon which results in a frameshift. The encoded isoform (b) has a distinct C-terminus and is longer than isoform a.
      Source sequence(s)
      AC019084, BX537845, DB069860
      Consensus CDS
      CCDS64816.1
      UniProtKB/TrEMBL
      B3KRQ2
      Related
      ENSP00000387007.3, ENST00000409339.3
      Conserved Domains (3) summary
      COG5096
      Location:339 → 484
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:368 → 405
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:213 → 361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    3. NM_017760.7 → NP_060230.5  condensin-2 complex subunit G2 isoform a

      See identical proteins and their annotated locations for NP_060230.5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC093662, BC043404, DB069860, DW419642
      Consensus CDS
      CCDS43686.1
      UniProtKB/Swiss-Prot
      A4D228, Q7Z3J9, Q86XI2, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6
      UniProtKB/TrEMBL
      B3KRQ2
      Related
      ENSP00000348657.3, ENST00000356309.8
      Conserved Domains (2) summary
      pfam12422
      Location:213 → 361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368 → 405
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_104054.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains three alternate exons and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC093662, BC028618, DB069860, DW419642
      Related
      ENST00000432615.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      158631169..158704804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420547.1 → XP_047276503.1  condensin-2 complex subunit G2 isoform X7

    2. XM_017012376.3 → XP_016867865.1  condensin-2 complex subunit G2 isoform X6

      UniProtKB/TrEMBL
      B3KRQ2

    3. XM_005249547.4 → XP_005249604.1  condensin-2 complex subunit G2 isoform X5

      See identical proteins and their annotated locations for XP_005249604.1

      UniProtKB/TrEMBL
      B3KRQ2
      Related
      ENSP00000408080.1, ENST00000441982.5
      Conserved Domains (2) summary
      pfam12422
      Location:213 → 361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368 → 405
      HEAT; HEAT repeat [structural motif]

    4. XM_047420548.1 → XP_047276504.1  condensin-2 complex subunit G2 isoform X7

    5. XM_047420546.1 → XP_047276502.1  condensin-2 complex subunit G2 isoform X6

    6. XM_047420544.1 → XP_047276500.1  condensin-2 complex subunit G2 isoform X5

    7. XM_047420545.1 → XP_047276501.1  condensin-2 complex subunit G2 isoform X5

    8. XM_047420539.1 → XP_047276495.1  condensin-2 complex subunit G2 isoform X2

      UniProtKB/Swiss-Prot
      A4D228, Q7Z3J9, Q86XI2, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6

    9. XM_011516362.2 → XP_011514664.1  condensin-2 complex subunit G2 isoform X9

      UniProtKB/TrEMBL
      B4DXB7

    10. XM_047420542.1 → XP_047276498.1  condensin-2 complex subunit G2 isoform X4

    11. XM_047420540.1 → XP_047276496.1  condensin-2 complex subunit G2 isoform X3

    12. XM_047420543.1 → XP_047276499.1  condensin-2 complex subunit G2 isoform X4

    13. XM_047420541.1 → XP_047276497.1  condensin-2 complex subunit G2 isoform X3

    14. XM_011516357.3 → XP_011514659.1  condensin-2 complex subunit G2 isoform X1

      See identical proteins and their annotated locations for XP_011514659.1

      UniProtKB/TrEMBL
      B3KRQ2
      Related
      ENST00000467785.5
      Conserved Domains (3) summary
      COG5096
      Location:339 → 484
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:368 → 405
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:213 → 361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    15. XM_047420538.1 → XP_047276494.1  condensin-2 complex subunit G2 isoform X1

    16. XM_011516358.4 → XP_011514660.1  condensin-2 complex subunit G2 isoform X8

      UniProtKB/TrEMBL
      B3KRQ2
      Conserved Domains (2) summary
      pfam12422
      Location:213 → 361
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:368 → 405
      HEAT; HEAT repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      159858401..159932192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358530.1 → XP_054214505.1  condensin-2 complex subunit G2 isoform X7

    2. XM_054358528.1 → XP_054214503.1  condensin-2 complex subunit G2 isoform X6

    3. XM_054358525.1 → XP_054214500.1  condensin-2 complex subunit G2 isoform X5

    4. XM_054358531.1 → XP_054214506.1  condensin-2 complex subunit G2 isoform X7

    5. XM_054358529.1 → XP_054214504.1  condensin-2 complex subunit G2 isoform X6

    6. XM_054358526.1 → XP_054214501.1  condensin-2 complex subunit G2 isoform X5

    7. XM_054358527.1 → XP_054214502.1  condensin-2 complex subunit G2 isoform X5

    8. XM_054358520.1 → XP_054214495.1  condensin-2 complex subunit G2 isoform X2

      UniProtKB/Swiss-Prot
      A4D228, Q7Z3J9, Q86XI2, Q8WUG8, Q9BRX6, Q9H8S2, Q9H9K6

    9. XM_054358533.1 → XP_054214508.1  condensin-2 complex subunit G2 isoform X9

    10. XM_054358523.1 → XP_054214498.1  condensin-2 complex subunit G2 isoform X4

    11. XM_054358521.1 → XP_054214496.1  condensin-2 complex subunit G2 isoform X3

    12. XM_054358524.1 → XP_054214499.1  condensin-2 complex subunit G2 isoform X4

    13. XM_054358522.1 → XP_054214497.1  condensin-2 complex subunit G2 isoform X3

    14. XM_054358518.1 → XP_054214493.1  condensin-2 complex subunit G2 isoform X1

    15. XM_054358519.1 → XP_054214494.1  condensin-2 complex subunit G2 isoform X1

    16. XM_054358532.1 → XP_054214507.1  condensin-2 complex subunit G2 isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86XI2.1 GenPept UniProtKB/Swiss-Prot:Q86XI2

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