ptprfa protein tyrosine phosphatase receptor type Fa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptprfaprovided by ZNC
Official Full Name: protein tyrosine phosphatase receptor type Faprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020107-2
See related: Ensembl:ENSDARG00000103479 AllianceGenome:ZFIN:ZDB-GENE-020107-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: LAR; ptprf
Summary: Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within sensory neuron axon guidance. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in nervous system; pectoral fin; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in hyperinsulinism. Orthologous to human PTPRF (protein tyrosine phosphatase receptor type F). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (2872081..3274493)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (2595911..3112871)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Presynaptic PTPsigma controls the number of olfactory sensory neuron and mitral cell synapses by suppressing excessive increase of axon terminals.
Title: Protein tyrosine phosphatase σ regulates the synapse number of zebrafish olfactory sensory neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

fj50d02.y1 (e-PCR)
- UniSTS:199467

G47949 (e-PCR)
- UniSTS:108715

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sensory neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic membrane adhesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein tyrosine phosphatase receptor type Fa; receptor-type tyrosine-protein phosphatase F

Names: protein tyrosine phosphatase, receptor type, f, a; zf-LAR

NP_001298277.1

EC 3.1.3.48

XP_021332435.1

EC 3.1.3.48

XP_021332436.1

EC 3.1.3.48

XP_021332437.1

EC 3.1.3.48

XP_021332438.1

EC 3.1.3.48

XP_021332439.1

EC 3.1.3.48

XP_021332440.1

EC 3.1.3.48

XP_021332441.1

EC 3.1.3.48

XP_021332442.1

EC 3.1.3.48

XP_021332443.1

EC 3.1.3.48

XP_021332444.1

EC 3.1.3.48

XP_021332445.1

EC 3.1.3.48

XP_021332446.1

EC 3.1.3.48

XP_021332447.1

EC 3.1.3.48

XP_021332448.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311348.1 → NP_001298277.1 protein tyrosine phosphatase receptor type Fa precursor

Status: VALIDATED

Source sequence(s)

JQ414007

UniProtKB/TrEMBL

H9CWQ2

Related

ENSDARP00000150663.1, ENSDART00000181271.1

Conserved Domains (9) summary

cd00096
Location:51 → 122

Ig; Immunoglobulin domain

cd05738
Location:153 → 227

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd05739
Location:247 → 315

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

smart00194
Location:1339 → 1593

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:142 → 226

IG_like; Immunoglobulin like

cd00047
Location:1364 → 1593

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:320 → 409

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:34 → 125

I-set; Immunoglobulin I-set domain

pfam00041
Location:609 → 696

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

2872081..3274493

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476761.1 → XP_021332436.1 receptor-type tyrosine-protein phosphatase F isoform X1

UniProtKB/TrEMBL

A0A8M9QA39

Conserved Domains (6) summary

cd05739
Location:256 → 324

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1388 → 1617

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:329 → 418

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam00041
Location:618 → 705

fn3; Fibronectin type III domain

cd05738
Location:152 → 232

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476760.1 → XP_021332435.1 receptor-type tyrosine-protein phosphatase F isoform X1

UniProtKB/TrEMBL

A0A8M9QA39

Conserved Domains (6) summary

cd05739
Location:256 → 324

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1388 → 1617

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:329 → 418

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam00041
Location:618 → 705

fn3; Fibronectin type III domain

cd05738
Location:152 → 232

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476763.1 → XP_021332438.1 receptor-type tyrosine-protein phosphatase F isoform X3

UniProtKB/TrEMBL

A0A8M9PZE9

Conserved Domains (6) summary

cd05739
Location:256 → 324

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1384 → 1613

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:329 → 418

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam00041
Location:618 → 705

fn3; Fibronectin type III domain

cd05738
Location:152 → 232

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476766.1 → XP_021332441.1 receptor-type tyrosine-protein phosphatase F isoform X6

UniProtKB/TrEMBL

A0A8M9QA45

Conserved Domains (6) summary

cd05739
Location:256 → 324

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1377 → 1606

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:329 → 418

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam00041
Location:618 → 705

fn3; Fibronectin type III domain

cd05738
Location:152 → 232

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476767.1 → XP_021332442.1 receptor-type tyrosine-protein phosphatase F isoform X7

UniProtKB/TrEMBL

A0A8M9PLU1

Conserved Domains (6) summary

cd05739
Location:256 → 324

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1373 → 1602

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:329 → 418

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam00041
Location:618 → 705

fn3; Fibronectin type III domain

cd05738
Location:152 → 232

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476768.1 → XP_021332443.1 receptor-type tyrosine-protein phosphatase F isoform X8

UniProtKB/TrEMBL

A0A8M9PZF5

Conserved Domains (5) summary

cd05739
Location:256 → 324

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1286 → 1515

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:329 → 418

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd05738
Location:152 → 232

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476762.1 → XP_021332437.1 receptor-type tyrosine-protein phosphatase F isoform X2

UniProtKB/TrEMBL

A0A8M9PLT7

Related

ENSDARP00000138975.2, ENSDART00000171014.2

Conserved Domains (6) summary

cd05739
Location:252 → 320

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1384 → 1613

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:325 → 414

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam00041
Location:614 → 701

fn3; Fibronectin type III domain

cd05738
Location:152 → 232

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476764.1 → XP_021332439.1 receptor-type tyrosine-protein phosphatase F isoform X4

UniProtKB/TrEMBL

A0A8M9Q5Y1

Conserved Domains (6) summary

cd05739
Location:250 → 318

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1382 → 1611

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:323 → 412

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam00041
Location:612 → 699

fn3; Fibronectin type III domain

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476765.1 → XP_021332440.1 receptor-type tyrosine-protein phosphatase F isoform X5

UniProtKB/TrEMBL

A0A8M9QF59

Related

ENSDARP00000145646.1, ENSDART00000183862.1

Conserved Domains (6) summary

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1378 → 1607

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

pfam00041
Location:608 → 695

fn3; Fibronectin type III domain

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476769.1 → XP_021332444.1 receptor-type tyrosine-protein phosphatase F isoform X9

UniProtKB/TrEMBL

A0A8M9Q5Y4

Conserved Domains (5) summary

cd05739
Location:252 → 320

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1282 → 1511

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:325 → 414

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd05738
Location:152 → 232

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476772.1 → XP_021332447.1 receptor-type tyrosine-protein phosphatase F isoform X12

UniProtKB/TrEMBL

A0A8M9PLU6

Conserved Domains (5) summary

cd05739
Location:252 → 320

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1278 → 1507

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:325 → 414

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd05738
Location:152 → 232

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476770.1 → XP_021332445.1 receptor-type tyrosine-protein phosphatase F isoform X10

UniProtKB/TrEMBL

A0A8M9QF62

Conserved Domains (5) summary

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1276 → 1505

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476773.1 → XP_021332448.1 receptor-type tyrosine-protein phosphatase F isoform X13

UniProtKB/TrEMBL

A0A8M9PZG0

Conserved Domains (5) summary

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1272 → 1501

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
XM_021476771.1 → XP_021332446.1 receptor-type tyrosine-protein phosphatase F isoform X11

UniProtKB/TrEMBL

A0A8M9QA48

Related

ENSDARP00000155993.1, ENSDART00000183181.1

Conserved Domains (5) summary

cd05739
Location:246 → 314

Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

cd00047
Location:1261 → 1490

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:319 → 408

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:33 → 124

I-set; Immunoglobulin I-set domain

cd05738
Location:152 → 226

Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR