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    ADGRF3 adhesion G protein-coupled receptor F3 [ Homo sapiens (human) ]

    Gene ID: 165082, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ADGRF3provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor F3provided by HGNC
    Primary source
    HGNC:HGNC:18989
    See related
    Ensembl:ENSG00000173567 MIM:620873; AllianceGenome:HGNC:18989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR23; GPR113
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRF3 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (26308173..26346789, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (26343551..26385469, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26531041..26569657, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene GRB2 associated regulator of MAPK1 subtype 2 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26465316-26465856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26467342-26468022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26468835-26469562 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene uncharacterized LOC105374334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26536028-26536873 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26540931-26541430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15470 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26568936-26569703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15471 Neighboring gene selenoprotein I Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15472 Neighboring gene dynein regulatory complex subunit 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26681071-26681640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26680500-26681070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26683329-26684034 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:26685720-26686919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26703326-26703826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26704893-26705698 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:26712674-26712916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15474 Neighboring gene otoferlin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26728504-26729004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26734217-26735140 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:26744163-26744328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26759696-26760624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26760625-26761553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26765926-26766660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26780985-26781778

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors. Carr JC, et al. Ann Surg Oncol, 2013 Dec. PMID 24114056, Free PMC Article
    2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. Fredriksson R, et al. FEBS Lett, 2002 Nov 20. PMID 12435584
    3. Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. Crockett DK, et al. Proteomics, 2005 Apr. PMID 15717329
    4. Identification of G protein-coupled receptor genes from the human genome sequence. Takeda S, et al. FEBS Lett, 2002 Jun 5. PMID 12044878
    5. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of GPR113 is associated with Small bowel primary and metastatic neuroendocrine tumors.
      Title: Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16767

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor F3
    Names
    G protein-coupled receptor 113
    G protein-coupled receptor PGR23
    probable G-protein coupled receptor 113
    seven transmembrane helix receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145168.1 → NP_001138640.1  adhesion G-protein coupled receptor F3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001138640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC010896, AY140955
      Consensus CDS
      CCDS46239.1
      UniProtKB/Swiss-Prot
      B4DF15, E9PEV1, Q53TA5, Q6UXT7, Q6UXX3, Q86SL7, Q8IXD8, Q8IZF5, Q8TDT3
      Related
      ENSP00000307831.1, ENST00000311519.5
      Conserved Domains (3) summary
      pfam01825
      Location:713 → 758
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:431 → 477
      HRM; Hormone receptor domain
      cl21561
      Location:770 → 1016
      7tm_4; Olfactory receptor

    2. NM_001145169.1 → NP_001138641.1  adhesion G-protein coupled receptor F3 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has alternate 5' and 3' sequences, as compared to variant 1. The resulting isoform (2) lacks an internal segment in the N-terminal region and has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AA459569, AK293887, AY140955, BC043211
      Consensus CDS
      CCDS46238.1
      UniProtKB/Swiss-Prot
      Q8IZF5
      Related
      ENSP00000388537.2, ENST00000421160.6
      Conserved Domains (3) summary
      cd15253
      Location:698 → 968
      7tmB2_GPR113; orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:362 → 408
      HRM; Hormone receptor domain
      pfam01825
      Location:644 → 689
      GPS; GPCR proteolysis site, GPS, motif

    3. NM_001321971.2 → NP_001308900.1  adhesion G-protein coupled receptor F3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC010896, AK293887, AY358172, BC043211
      Consensus CDS
      CCDS92721.1
      UniProtKB/TrEMBL
      A0A494C083
      Related
      ENSP00000498434.1, ENST00000651242.2
      Conserved Domains (3) summary
      pfam01825
      Location:645 → 690
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:363 → 409
      HRM; Hormone receptor domain
      cl21561
      Location:702 → 948
      7tm_4; Olfactory receptor

    4. NM_001321975.2 → NP_001308904.1  adhesion G-protein coupled receptor F3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC010896, AY140955, BC043211, HY209981
      UniProtKB/TrEMBL
      B3KVM9
      Related
      ENST00000459892.5
      Conserved Domains (3) summary
      cd15253
      Location:370 → 640
      7tmB2_GPR113; orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:316 → 361
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:34 → 80
      HRM; Hormone receptor domain

    5. NM_001393343.1 → NP_001380272.1  adhesion G-protein coupled receptor F3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC010896
      UniProtKB/TrEMBL
      B3KVM9
      Conserved Domains (3) summary
      cd15253
      Location:370 → 640
      7tmB2_GPR113; orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:316 → 361
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:34 → 80
      HRM; Hormone receptor domain

    6. NM_153835.4 → NP_722577.2  adhesion G-protein coupled receptor F3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has alternate 5' and 3' sequences and lacks two internal in-frame coding exons, as compared to variant 1. The resulting isoform (3) has shorter and different N- and C-termini and lack an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC010896, AY358172, BC043211
      Consensus CDS
      CCDS33159.2
      UniProtKB/Swiss-Prot
      Q8IZF5
      Related
      ENSP00000327396.6, ENST00000333478.10
      Conserved Domains (3) summary
      pfam01825
      Location:514 → 559
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:232 → 278
      HRM; Hormone receptor domain
      cl21561
      Location:571 → 817
      7tm_4; Olfactory receptor

    RNA

    1. NR_135916.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AY140955, AY358172, BC043211
      Related
      ENST00000435303.1

    2. NR_171656.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010896

    3. NR_171657.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC010896

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      26308173..26346789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443563.1 → XP_047299519.1  adhesion G-protein coupled receptor F3 isoform X2

    2. XM_011532621.4 → XP_011530923.1  adhesion G-protein coupled receptor F3 isoform X1

      Conserved Domains (3) summary
      pfam01825
      Location:654 → 699
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:372 → 418
      HRM; Hormone receptor domain
      cl21561
      Location:711 → 957
      7tm_4; Olfactory receptor

    3. XM_047443565.1 → XP_047299521.1  adhesion G-protein coupled receptor F3 isoform X5

    4. XM_011532622.3 → XP_011530924.1  adhesion G-protein coupled receptor F3 isoform X3

      Conserved Domains (3) summary
      pfam01825
      Location:644 → 689
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:362 → 408
      HRM; Hormone receptor domain
      cl21561
      Location:701 → 947
      7tm_4; Olfactory receptor

    5. XM_047443564.1 → XP_047299520.1  adhesion G-protein coupled receptor F3 isoform X4

    6. XM_011532623.3 → XP_011530925.1  adhesion G-protein coupled receptor F3 isoform X4

      See identical proteins and their annotated locations for XP_011530925.1

      Conserved Domains (3) summary
      pfam01825
      Location:638 → 683
      GPS; GPCR proteolysis site, GPS, motif
      pfam02793
      Location:356 → 402
      HRM; Hormone receptor domain
      cl21561
      Location:695 → 941
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      26343551..26385469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340854.1 → XP_054196829.1  adhesion G-protein coupled receptor F3 isoform X6

    2. XM_054340855.1 → XP_054196830.1  adhesion G-protein coupled receptor F3 isoform X5

    3. XM_054340850.1 → XP_054196825.1  adhesion G-protein coupled receptor F3 isoform X2

    4. XM_054340849.1 → XP_054196824.1  adhesion G-protein coupled receptor F3 isoform X1

    5. XM_054340851.1 → XP_054196826.1  adhesion G-protein coupled receptor F3 isoform X3

    6. XM_054340853.1 → XP_054196828.1  adhesion G-protein coupled receptor F3 isoform X4

    7. XM_054340852.1 → XP_054196827.1  adhesion G-protein coupled receptor F3 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZF5.1 GenPept UniProtKB/Swiss-Prot:Q8IZF5

    Gene LinkOut

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