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    IPO8 importin 8 [ Homo sapiens (human) ]

    Gene ID: 10526, updated on 3-Nov-2024

    Summary

    Official Symbol
    IPO8provided by HGNC
    Official Full Name
    importin 8provided by HGNC
    Primary source
    HGNC:HGNC:9853
    See related
    Ensembl:ENSG00000133704 MIM:605600; AllianceGenome:HGNC:9853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VISS; RANBP8
    Summary
    The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 11.8), testis (RPKM 10.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See IPO8 in Genome Data Viewer
    Location:
    12p11.21
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (30628988..30695869, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (30503650..30570532, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (30781922..30848803, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:30637986-30638520 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28085 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28118 Neighboring gene uncharacterized LOC105369719 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28131 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:30756793-30757482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:30757483-30758172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6158 Neighboring gene caprin family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4322 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:30909210-30909413 Neighboring gene uncharacterized LOC645485

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ21954, FLJ26580

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables small GTPase binding  
    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in cytosol  
    is_active_in nuclear envelope  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    importin-8
    Names
    RAN binding protein 8
    imp8
    ran-binding protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190995.2NP_001177924.1  importin-8 isoform 2

      See identical proteins and their annotated locations for NP_001177924.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several 5' exons, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK130090, AK302260, BG574795, DB067822, DC400226, EB387074
      Consensus CDS
      CCDS53773.1
      UniProtKB/Swiss-Prot
      O15397
      Related
      ENSP00000444520.1, ENST00000544829.5
      Conserved Domains (2) summary
      COG5656
      Location:9791
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
      pfam03378
      Location:536664
      CAS_CSE1; CAS/CSE protein, C-terminus
    2. NM_006390.4NP_006381.2  importin-8 isoform 1

      See identical proteins and their annotated locations for NP_006381.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK130090, AK302260, BG574795, DB067822, DB072643, DB088518, EB387074, U77494
      Consensus CDS
      CCDS8719.1
      UniProtKB/Swiss-Prot
      B7Z7M3, O15397
      Related
      ENSP00000256079.4, ENST00000256079.9
      Conserved Domains (3) summary
      COG5656
      Location:15996
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
      pfam03378
      Location:741869
      CAS_CSE1; CAS/CSE protein, C-terminus
      pfam03810
      Location:22101
      IBN_N; Importin-beta N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      30628988..30695869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018691.3XP_016874180.1  importin-8 isoform X1

    2. XM_017018692.2XP_016874181.1  importin-8 isoform X2

    3. XM_017018693.3XP_016874182.1  importin-8 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      30503650..30570532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370778.1XP_054226753.1  importin-8 isoform X4

    2. XM_054370777.1XP_054226752.1  importin-8 isoform X1

    3. XM_054370779.1XP_054226754.1  importin-8 isoform X2

    4. XM_054370780.1XP_054226755.1  importin-8 isoform X3

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