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    YHK8 Yhk8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856444, updated on 17-May-2024

    Summary

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    Gene symbol
    YHK8
    Gene description
    Yhk8p
    Primary source
    FungiDB:YHR048W
    Locus tag
    YHR048W
    See related
    SGD:S000001090; AllianceGenome:SGD:S000001090; VEuPathDB:YHR048W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable xenobiotic transmembrane transporter activity. Predicted to be involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Located in cell periphery. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YHK8 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (204607..206151)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene inositol monophosphate 1-phosphatase INM1 Neighboring gene arginine/alanine aminopeptidase Neighboring gene putative serine hydrolase Neighboring gene divalent metal ion transporter SMF2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multidrug-resistant transport proteins in yeast: complete inventory and phylogenetic characterization of yeast open reading frames with the major facilitator superfamily. Goffeau A, et al. Yeast, 1997 Jan. PMID 9046086
    2. Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae. Barker KS, et al. J Antimicrob Chemother, 2003 May. PMID 12697649
    3. Evolution of the 12-spanner drug:H+ antiporter DHA1 family in hemiascomycetous yeasts. Dias PJ, et al. OMICS, 2010 Dec. PMID 21114408
    4. FACT interacts with Set3 HDAC and fine-tunes GAL1 transcription in response to environmental stimulation. Leng H, et al. Nucleic Acids Res, 2021 Jun 4. PMID 33963860, Free PMC Article
    5. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Johnston M, et al. Science, 1994 Sep 30. PMID 8091229

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Yhk8p
    NP_011914.1
    • Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      204607..206151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179178.1 → NP_011914.1  TPA: Yhk8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011914.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKZ6, P38776
      UniProtKB/TrEMBL
      A0A8H4BZI4, A6ZSV5, B5VJX9, C7GT87, C8ZAB9, N1P9M5
      Conserved Domains (1) summary
      cd17323
      Location:77 → 505
      MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38776.1

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