Tipin timeless interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tipinprovided by RGD
Official Full Name: timeless interacting proteinprovided by RGD
Primary source: RGD:1564084
See related: EnsemblRapid:ENSRNOG00000043068 AllianceGenome:RGD:1564084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: UV98; RGD1564084
Summary: The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]
Expression: Biased expression in Thymus (RPKM 124.7), Spleen (RPKM 98.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (73676020..73696620)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (64780813..64801358)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (69753363..69768640)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139218 (e-PCR)
- UniSTS:221304

RH140249 (e-PCR)
- UniSTS:222328

AU028773 (e-PCR)
- UniSTS:112000

BE100135 (e-PCR)
- UniSTS:249778

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in DNA replication checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in DNA replication checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell cycle phase transition	ISO Inferred from Sequence Orthology more info
involved_in cell cycle phase transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic intra-S DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic intra-S DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork arrest	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to UV	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of replication fork protection complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TIMELESS-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.