sbno1 strawberry notch homolog 1 (Drosophila) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sbno1provided by ZNC
Official Full Name: strawberry notch homolog 1 (Drosophila)provided by ZNC
Primary source: ZFIN:ZDB-GENE-080522-2
See related: Ensembl:ENSDARG00000099080 AllianceGenome:ZFIN:ZDB-GENE-080522-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable chromatin DNA binding activity and histone binding activity. Acts upstream of or within neural plate anterior/posterior regionalization. Predicted to be active in nucleus. Is expressed in central nervous system; eye; immature eye; neural tube; and otic vesicle. Used to study schizophrenia. Orthologous to human SBNO1 (strawberry notch homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (44309575..44358183, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (44421792..44441266, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of sbno1 specifically affects regionalization along the anterior-posterior axis of the brain.
Title: Function of strawberry notch family genes in the zebrafish brain development.
The sbno1 gene gradually became predominant in the central nervous system.
Title: Expression of strawberry notch family genes during zebrafish embryogenesis.

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General gene information

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Markers

G40425 (e-PCR)
- UniSTS:65066

z6346 (e-PCR), detects polymorphism
- UniSTS:204875

G47185 (e-PCR)
- UniSTS:107972

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within neural plate anterior/posterior regionalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein strawberry notch homolog 1

Names: strawberry notch homologue 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.