rap1b RAP1B, member of RAS oncogene family [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rap1bprovided by ZNC
Official Full Name: RAP1B, member of RAS oncogene familyprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9662
See related: Ensembl:ENSDARG00000008867 AllianceGenome:ZFIN:ZDB-GENE-030131-9662
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb119; cb1026; sb:cb119; wu:fb11c04; wu:fb74e09; wu:fk70e05
Summary: Enables MAP kinase kinase activity. Acts upstream of with a positive effect on hematopoietic stem cell differentiation. Acts upstream of or within chordate embryonic development; convergent extension; and heart development. Located in cell-cell junction. Is expressed in several structures, including brain; cardiovascular system; floor plate; hindbrain neural plate; and mesoderm. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including RAP1B (RAP1B, member of RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (18853457..18939338, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (18864481..18950362, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rap1b activates Integrin/Fibronectin receptors as part of an "inside-out" signaling pathway that promotes Integrin binding to FN, FN matrix assembly, and subsequent stabilization of morphological somite boundaries.
Title: Segmental assembly of fibronectin matrix requires rap1b and integrin α5.
Using 2 distinct pharmacologic VEGFR2 inhibitors the study shows that rap1b and VEGFR2 act additively to control angiogenesis in vivo.
Title: Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃.

Submit: New GeneRIF Correction

General gene information

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Markers

fb11c04.x1 (e-PCR)
- UniSTS:190026

fb11c04.x1 (e-PCR)
- UniSTS:190027

fb74e09 (e-PCR)
- UniSTS:187473

fk31c05.y1 (e-PCR)
- UniSTS:200800

fb74e09.x1 (e-PCR)
- UniSTS:191205

fk70e05.x1 (e-PCR)
- UniSTS:201446

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rap protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rap protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chondrocyte intercalation involved in growth plate cartilage morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somite rostral/caudal axis specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rap-1b

Names: RAS related protein 1b

NP_955827.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199533.1 → NP_955827.1 ras-related protein Rap-1b

See identical proteins and their annotated locations for NP_955827.1

Status: PROVISIONAL

Source sequence(s)

BC044548

UniProtKB/Swiss-Prot

Q6TEN1

Related

ENSDARP00000042249.5, ENSDART00000042250.6

Conserved Domains (2) summary

cd04175
Location:3 → 167

Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

smart00010
Location:2 → 168

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily