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    PAL1 Pal1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851949, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAL1
    Official Full Name
    Pal1p
    Primary source
    SGD:S000002756
    Locus tag
    YDR348C
    See related
    AllianceGenome:SGD:S000002756; FungiDB:YDR348C; VEuPathDB:YDR348C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in endocytosis. Located in actin cortical patch. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PAL1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1170326..1171825, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Svf1p Neighboring gene mitochondrial 37S ribosomal protein MRP1 Neighboring gene putative aspartic endopeptidase Neighboring gene tRNA-Met

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Suppressor of Clathrin Deficiency-1 (SCD1) and Its Connection to Clathrin-Mediated Endocytosis in Saccharomyces cerevisiae. Moorthy BT, et al. G3 (Bethesda), 2019 Mar 7. PMID 30679249, Free PMC Article
    2. Analysis of yeast endocytic site formation and maturation through a regulatory transition point. Carroll SY, et al. Mol Biol Cell, 2012 Feb. PMID 22190733, Free PMC Article
    3. TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids. Muir A, et al. Elife, 2014 Oct 3. PMID 25279700, Free PMC Article
    4. Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase. Wood CS, et al. Mol Biol Cell, 2012 Jul. PMID 22553352, Free PMC Article
    5. Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast. Ghosh C, et al. Sci Signal, 2021 May 25. PMID 34035143, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud tip HDA PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mating projection tip HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pal1p
    NP_010635.1
    • hypothetical protein thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluorescent protein (GFP)-fusion protein localizes to bud neck; potential Cdc28p substrate; similar to S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress; PAL1 has a paralog, YHR097C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1170326..1171825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180656.1 → NP_010635.1  TPA: Pal1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010635.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSX8, Q05518, Q66RD5
      UniProtKB/TrEMBL
      A6ZYU8, B3LFV2, C8Z5Q9, N1PAI3
      Conserved Domains (1) summary
      pfam08316
      Location:236 → 369
      Pal1; Pal1 cell morphology protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05518.1

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