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    EGD2 Egd2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856600, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EGD2
    Official Full Name
    Egd2p
    Primary source
    SGD:S000001236
    Locus tag
    YHR193C
    See related
    AllianceGenome:SGD:S000001236; FungiDB:YHR193C; VEuPathDB:YHR193C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phospholipid binding activity and unfolded protein binding activity. Involved in posttranslational protein targeting to endoplasmic reticulum membrane. Part of nascent polypeptide-associated complex. Orthologous to several human genes including NACA2 (nascent polypeptide associated complex subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EGD2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (487712..488236, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ctf8p Neighboring gene Lnp1p Neighboring gene Mdm31p Neighboring gene Nvj1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for a nuclear passage of nascent polypeptide-associated complex subunits in yeast. Franke J, et al. J Cell Sci, 2001 Jul. PMID 11683391
    2. The yeast EGD2 gene encodes a homologue of the alpha NAC subunit of the human nascent-polypeptide-associated complex. Shi X, et al. Gene, 1995 Nov 20. PMID 8522175
    3. OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria. Lesnik C, et al. Nat Commun, 2014 Dec 9. PMID 25487825, Free PMC Article
    4. Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast. Takahashi T, et al. J Toxicol Sci, 2009 Dec. PMID 19952507
    5. The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane. Wiedmann B, et al. FEBS Lett, 1999 Sep 10. PMID 10518932

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
      Title: Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cotranslational protein targeting to membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nascent polypeptide-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nascent polypeptide-associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Egd2p
    NP_012063.3
    • Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      487712..488236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179324.3 → NP_012063.3  TPA: Egd2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012063.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZT99, D3DLE1, P38879
      UniProtKB/TrEMBL
      B3LSV4, B5VKC1, C7GRL5, C8Z9Z2, G2WFR6, N1P9I5
      Conserved Domains (1) summary
      COG1308
      Location:3 → 174
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38879.3

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