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    MRC2 mannose receptor C-type 2 [ Homo sapiens (human) ]

    Gene ID: 9902, updated on 3-Nov-2024

    Summary

    Official Symbol
    MRC2provided by HGNC
    Official Full Name
    mannose receptor C-type 2provided by HGNC
    Primary source
    HGNC:HGNC:16875
    See related
    Ensembl:ENSG00000011028 MIM:612264; AllianceGenome:HGNC:16875
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD280; UPARAP; CLEC13E; ENDO180
    Summary
    This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
    Expression
    Ubiquitous expression in gall bladder (RPKM 26.1), ovary (RPKM 24.7) and 24 other tissues See more
    Orthologs
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    Genomic context

    See MRC2 in Genome Data Viewer
    Location:
    17q23.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62627670..62693597)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63497612..63563512)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60705031..60770958)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541227-60541728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541729-60542228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8808 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:60562255-60562754 Neighboring gene MPRA-validated peak2934 silencer Neighboring gene tousled like kinase 2 Neighboring gene ribosomal protein S10 pseudogene 26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:60622822-60623322 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60636816-60637174 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:60642433-60643632 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60645420-60645891 Neighboring gene MPRA-validated peak2935 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60696223-60696734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60702756-60703256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60703257-60703757 Neighboring gene uncharacterized LOC107985020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60707912-60708768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729214-60729925 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729926-60730636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60731349-60732059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60743431-60744021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60746820-60747579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60747580-60748338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60748658-60749158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60749159-60749659 Neighboring gene Sharpr-MPRA regulatory region 5505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60757143-60757871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60769301-60769962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60769963-60770624 Neighboring gene RNA, U6 small nuclear 446, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8811 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60781806-60782032 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:60782895-60783686 Neighboring gene uncharacterized LOC105371855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12542 Neighboring gene membrane associated ring-CH-type finger 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12543 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:60817295-60817950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60827154-60827763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60827764-60828372 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:60839055-60839580 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60839581-60840107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8813 Neighboring gene MARCHF10 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60902506-60903242

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binds to mannose receptor on vaginal epithelial cells PubMed
    env Mannose receptor (MR) dimers bind to soluble monomeric and trimeric HIV envelope and to HIV virion in capture assay PubMed
    env Recombinant HIV-1 gp120 blocks Mannose Receptor-mediated phagocytosis in human and murine macrophages and microglial cells PubMed
    env HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin PubMed
    env HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes PubMed
    Tat tat HIV-1 Tat represses transcription from the rat mannose receptor promoter, thereby downregulating expression of mannose receptor PubMed
    tat HIV-1 Tat interaction with cyclin T1 is required for the repression of mannose receptor (MR) and bone morphogenetic protein receptor-2 (BMPR2) promoters PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • FLJ35911, KIAA0709

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding  
    enables collagen binding PubMed 
    enables protein binding PubMed 
    enables signaling receptor activity  

    General protein information

    Preferred Names
    C-type mannose receptor 2
    Names
    C-type lectin domain family 13 member E
    UPAR-associated protein
    endocytic receptor (macrophage mannose receptor family)
    endocytic receptor 180
    macrophage mannose receptor 2
    urokinase-type plasminogen activator receptor-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033955.1 RefSeqGene

      Range
      5270..71197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006039.5NP_006030.2  C-type mannose receptor 2 precursor

      See identical proteins and their annotated locations for NP_006030.2

      Status: REVIEWED

      Source sequence(s)
      AI458446, BC032763, BC146647, BC153884
      Consensus CDS
      CCDS11634.1
      UniProtKB/Swiss-Prot
      A6H8K4, D3DU08, Q7LGE7, Q9UBG0, Q9Y5P9
      Related
      ENSP00000307513.5, ENST00000303375.10
      Conserved Domains (5) summary
      smart00059
      Location:180228
      FN2; Fibronectin type 2 domain
      cd00037
      Location:247361
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      smart00034
      Location:382505
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00458
      Location:46161
      RICIN; Ricin-type beta-trefoil
      cd00161
      Location:43127
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      62627670..62693597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437208.1XP_047293164.1  C-type mannose receptor 2 isoform X2

    2. XM_011525543.2XP_011523845.1  C-type mannose receptor 2 isoform X1

      Conserved Domains (5) summary
      smart00059
      Location:180228
      FN2; Fibronectin type 2 domain
      cd00037
      Location:247361
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      smart00034
      Location:382505
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00458
      Location:46161
      RICIN; Ricin-type beta-trefoil
      cd00161
      Location:43127
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      63497612..63563512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318061.1XP_054174036.1  C-type mannose receptor 2 isoform X2

    2. XM_054318060.1XP_054174035.1  C-type mannose receptor 2 isoform X1

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