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    KEI1 Kei1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851973, updated on 2-Nov-2024

    Summary

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    Official Symbol
    KEI1
    Official Full Name
    Kei1p
    Primary source
    SGD:S000002775
    Locus tag
    YDR367W
    See related
    AllianceGenome:SGD:S000002775; FungiDB:YDR367W; VEuPathDB:YDR367W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables inositol phosphoceramide synthase regulator activity. Involved in inositol phosphoceramide metabolic process. Located in Golgi membrane. Part of inositol phosphoceramide synthase complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See KEI1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (1212848..1213614)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene Mor1p Neighboring gene trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 Neighboring gene Xrs2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization. Sato K, et al. Mol Biol Cell, 2009 Oct. PMID 19726565, Free PMC Article
    2. Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide. Snyder NA, et al. G3 (Bethesda), 2019 Mar 7. PMID 30670608, Free PMC Article
    3. The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy. Liu S, et al. Nat Commun, 2023 Jun 22. PMID 37349354, Free PMC Article
    4. Orm proteins integrate multiple signals to maintain sphingolipid homeostasis. Gururaj C, et al. J Biol Chem, 2013 Jul 12. PMID 23737533, Free PMC Article
    5. Assigning function to yeast proteins by integration of technologies. Hazbun TR, et al. Mol Cell, 2003 Dec. PMID 14690591

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables inositol phosphoceramide synthase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol phosphoceramide synthase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol phosphoceramide synthase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inositol phosphoceramide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphoceramide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inositol phosphoceramide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    part_of inositol phosphoceramide synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inositol phosphoceramide synthase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kei1p
    NP_010655.1
    • Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1212848..1213614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180675.1 → NP_010655.1  TPA: Kei1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010655.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSZ8, Q06346, Q06999
      UniProtKB/TrEMBL
      A6ZYW5, C7GMH0, C8Z5S8, G2WBA3, N1P5D5
      Conserved Domains (1) summary
      pfam08552
      Location:11 → 182
      Kei1; Inositolphosphorylceramide synthase subunit Kei1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06346.2

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