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    APL6 Apl6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853177, updated on 17-May-2024

    Summary

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    Gene symbol
    APL6
    Gene description
    Apl6p
    Primary source
    FungiDB:YGR261C
    Locus tag
    YGR261C
    See related
    SGD:S000003493; AllianceGenome:SGD:S000003493; VEuPathDB:YGR261C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YKS5
    Summary
    Involved in Golgi to vacuole transport and protein targeting to vacuole. Located in cytosol. Part of AP-3 adaptor complex. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome (multiple); developmental and epileptic encephalopathy 48; interstitial lung disease (multiple); and neutropenia. Orthologous to several human genes including AP3B2 (adaptor related protein complex 3 subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See APL6 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1014321..1016750, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ssDNA endodeoxyribonuclease RAD2 Neighboring gene Tna1p Neighboring gene serine/threonine protein kinase BUD32 Neighboring gene steryl deacetylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the yeast R-SNARE Nyv1p as a novel longin domain-containing protein. Wen W, et al. Mol Biol Cell, 2006 Oct. PMID 16855025, Free PMC Article
    2. A genome-wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity. Garza NM, et al. J Biol Chem, 2021 Jan-Jun. PMID 33662401, Free PMC Article
    3. Analysis of an 11.6 kb region from the right arm of chromosome VII of Saccharomyces cerevisiae between the RAD2 and the MES1 genes reveals the presence of three new genes. Clemente ML, et al. Yeast, 1997 Mar 15. PMID 9090059
    4. Genetically encoded multimode reporter of adaptor complex 3 traffic in budding yeast. Plemel RL, et al. Traffic, 2021 Jan. PMID 33225520, Free PMC Article
    5. The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane. Llinares E, et al. Sci Rep, 2015 Nov 18. PMID 26577948, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Apl6p
    NP_011777.3
    • Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1014321..1016750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181390.3 → NP_011777.3  TPA: Apl6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011777.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV40, P46682
      UniProtKB/TrEMBL
      A0A8H8UKZ3, B3LHY1, B5VJK3, C7GNH1, C8Z9F3, N1P9Z4
      Conserved Domains (2) summary
      COG5096
      Location:6 → 770
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:119 → 146
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46682.2

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