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    NEO1 putative aminophospholipid-translocating P4-type ATPase NEO1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854763, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NEO1
    Official Full Name
    putative aminophospholipid-translocating P4-type ATPase NEO1
    Primary source
    SGD:S000001310
    Locus tag
    YIL048W
    See related
    AllianceGenome:SGD:S000001310; FungiDB:YIL048W; VEuPathDB:YIL048W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including phospholipid translocation; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; and vacuole organization. Located in Golgi membrane; late endosome; and trans-Golgi network. Is active in plasma membrane. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth and behavioral abnormalities. Orthologous to several human genes including ATP9B (ATPase phospholipid transporting 9B (putative)). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See NEO1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (261437..264892)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Pcl7p Neighboring gene putative polyprenol reductase Neighboring gene Syg1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and phylogenetic classification of eleven putative P-type calcium transport ATPase genes in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Catty P, et al. Biosci Rep, 1996 Apr. PMID 8790914
    2. Identification of an overexpressed yeast gene which prevents aminoglycoside toxicity. Prezant TR, et al. Microbiology (Reading), 1996 Dec. PMID 9004503
    3. Conserved mechanism of phospholipid substrate recognition by the P4-ATPase Neo1 from Saccharomyces cerevisiae. Huang Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2020 Feb. PMID 31786280, Free PMC Article
    4. The Essential Neo1 Protein from Budding Yeast Plays a Role in Establishing Aminophospholipid Asymmetry of the Plasma Membrane. Takar M, et al. J Biol Chem, 2016 Jul 22. PMID 27235400, Free PMC Article
    5. Yeast Dop1 is required for glycosyltransferase retrieval from the trans-Golgi network. Zhao SB, et al. Biochim Biophys Acta Gen Subj, 2019 Jun. PMID 30981741

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis of the P4B ATPase lipid flippase activity.
      Title: Structural basis of the P4B ATPase lipid flippase activity.
    2. The Any1 coimmunoprecipitates with Neo1, an association prevented by the Any1-inactivating mutation D84G.
      Title: The PQ-loop protein Any1 segregates Drs2 and Neo1 functions required for viability and plasma membrane phospholipid asymmetry.
    3. Study found that residues critical for phospholipid substrate recognition in P4A-ATPases from yeast to man are essential for function of an evolutionarily distant P4B-ATPase Neo1 from Saccharomyces cerevisiae.
      Title: Conserved mechanism of phospholipid substrate recognition by the P4-ATPase Neo1 from Saccharomyces cerevisiae.
    4. These results indicate that Neo1 plays an important role in establishing PS and PE plasma membrane asymmetry in budding yeast.
      Title: The Essential Neo1 Protein from Budding Yeast Plays a Role in Establishing Aminophospholipid Asymmetry of the Plasma Membrane.
    5. Data show that Dop1p localizes to endosomes and exists in a complex with Neo1p-Ysl2p-Arl1p.
      Title: Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylethanolamine flippase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine flippase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine floppase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminophospholipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative aminophospholipid-translocating P4-type ATPase NEO1
    NP_012216.1
    • Phospholipid translocase (flippase); involved in generating phospholipid asymmetry in plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi-to-ER vesicle-mediated transport; localizes to endosomes and Golgi apparatus; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      261437..264892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179398.1 → NP_012216.1  TPA: putative aminophospholipid-translocating P4-type ATPase NEO1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012216.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVN3, P40527
      UniProtKB/TrEMBL
      A6ZVM1, B3LTQ4, B5VKP8, C7GVX6, C8ZAJ8, G2WG97, N1P436
      Conserved Domains (2) summary
      cd07541
      Location:172 → 1067
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:574 → 670
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40527.1

    Gene LinkOut

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