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    GPI14 glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853470, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPI14
    Official Full Name
    glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I
    Primary source
    SGD:S000003774
    Locus tag
    YJR013W
    See related
    AllianceGenome:SGD:S000003774; FungiDB:YJR013W; VEuPathDB:YJR013W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PMH1
    Summary
    Contributes to mannosyltransferase activity. Involved in GPI anchor biosynthetic process and fungal-type cell wall organization. Located in endoplasmic reticulum. Part of glycosylphosphatidylinositol-mannosyltransferase I complex. Orthologous to human PIGM (phosphatidylinositol glycan anchor biosynthesis class M). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GPI14 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (460382..461593)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Cal4p Neighboring gene uncharacterized protein Neighboring gene Tma22p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Both mammalian PIG-M and PIG-X are required for growth of GPI14-disrupted yeast. Kim YU, et al. J Biochem, 2007 Jul. PMID 17519279
    2. PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. Maeda Y, et al. EMBO J, 2001 Jan 15. PMID 11226175, Free PMC Article
    3. Characterization of GPI14/YJR013w mutation that induces the cell wall integrity signalling pathway and results in increased protein production in Saccharomyces cerevisiae. Davydenko SG, et al. Yeast, 2005 Sep. PMID 16134120
    4. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Ashida H, et al. Mol Biol Cell, 2005 Mar. PMID 15635094, Free PMC Article
    5. TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks. Shimada K, et al. Mol Cell, 2013 Sep 26. PMID 24035500

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,4-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycolipid mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of glycosylphosphatidylinositol-mannosyltransferase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycosylphosphatidylinositol-mannosyltransferase I complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I
    NP_012547.2
    • Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I; involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      460382..461593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181671.1 → NP_012547.2  TPA: glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012547.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWI9, E9P8R4, P47088
      UniProtKB/TrEMBL
      B3LQB2, D3UF77, G2WH25, N1P1H3
      Conserved Domains (1) summary
      pfam05007
      Location:127 → 386
      Mannosyl_trans; Mannosyltransferase (PIG-M)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47088.2

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