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    CSC1 Csc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850942, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CSC1
    Official Full Name
    Csc1p
    Primary source
    SGD:S000004231
    Locus tag
    YLR241W
    See related
    AllianceGenome:SGD:S000004231; FungiDB:YLR241W; VEuPathDB:YLR241W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables calcium-activated cation channel activity. Involved in monoatomic cation transport. Located in endoplasmic reticulum and fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 87 and hypomyelinating leukodystrophy 19. Orthologous to several human genes including TMEM63A (transmembrane protein 63A). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See CSC1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (620473..622821)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene lipoyl(octanoyl) transferase LIP2 Neighboring gene phosphatidylinositol 3-kinase VPS34 Neighboring gene sterol homeostasis protein ARV1 Neighboring gene putative signal sequence-binding GTPase GPN3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Finding motifs in protein secondary structure for use in function prediction. Ferré S, et al. J Comput Biol, 2006 Apr. PMID 16706721
    2. DUF221 proteins are a family of osmosensitive calcium-permeable cation channels conserved across eukaryotes. Hou C, et al. Cell Res, 2014 May. PMID 24503647, Free PMC Article
    3. A genome-wide synthetic dosage lethality screen reveals multiple pathways that require the functioning of ubiquitin-binding proteins Rad23 and Dsk2. Liu C, et al. BMC Biol, 2009 Nov 12. PMID 19909498, Free PMC Article
    4. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
    5. The peroxisomal exportomer directly inhibits phosphoactivation of the pexophagy receptor Atg36 to suppress pexophagy in yeast. Yu H, et al. Elife, 2022 Apr 11. PMID 35404228, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-activated cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Csc1p
    NP_013342.1
    • Calcium permeable gated cation channel; functions as an osmosensitive, calcium-permeable cation channel when expressed in a heterologous system; may be involved in detoxification; similar to Arabidopsis CSC1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      620473..622821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182128.1 → NP_013342.1  TPA: Csc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013342.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYN9, Q06538
      UniProtKB/TrEMBL
      A7A1C4, B3RHC6, B5VNF8, C7GQZ5, C8ZDK4, G2WJ67, N1NZV5
      Conserved Domains (1) summary
      COG5594
      Location:1 → 782
      COG5594; Uncharacterized integral membrane protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06538.1

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