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    adcyap1b adenylate cyclase activating polypeptide 1b [ Danio rerio (zebrafish) ]

    Gene ID: 335625, updated on 12-Sep-2024

    Summary

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    Official Symbol
    adcyap1bprovided by ZNC
    Official Full Name
    adenylate cyclase activating polypeptide 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-89
    See related
    Ensembl:ENSDARG00000027740 AllianceGenome:ZFIN:ZDB-GENE-041010-89
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    PACAP2; acap1l; pacap1b; GHRH-LP2; zgc:92555; wu:fj30e08; zgc:101522
    Summary
    Predicted to enable neuropeptide hormone activity; peptide hormone receptor binding activity; and pituitary adenylate cyclase activating polypeptide activity. Acts upstream of or within brain development and camera-type eye development. Predicted to be located in extracellular region. Predicted to be active in neuron projection and perikaryon. Is expressed in several structures, including basal plate midbrain region; male organism; nervous system; spleen; and trigeminal placode. Orthologous to human ADCYAP1 (adenylate cyclase activating polypeptide 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See adcyap1b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31297150..31302661, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31313932..31319443, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487471 Neighboring gene uncharacterized LOC137487898 Neighboring gene uncharacterized LOC101885430 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene clusterin-like 1 (retinal) Neighboring gene collectin sub-family member 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Distribution of pituitary adenylate cyclase-activating polypeptide 2 in zebrafish brain. Nakamachi T, et al. Peptides, 2018 May. PMID 29535004
    2. Differential regulation of kit ligand A (kitlga) expression in the zebrafish ovarian follicle cells--evidence for the existence of a cyclic adenosine 3', 5' monophosphate-mediated binary regulatory system during folliculogenesis. Yao K, et al. Mol Cell Endocrinol, 2015 Feb 15. PMID 25542847
    3. Cloning, regulation of messenger ribonucleic acid expression, and function of a new isoform of pituitary adenylate cyclase-activating polypeptide in the zebrafish ovary. Wang Y, et al. Endocrinology, 2003 Nov. PMID 12959988
    4. Distribution of growth hormone-releasing hormone-like peptide: Immunoreactivity in the central nervous system of the adult zebrafish (Danio rerio). Castro A, et al. J Comp Neurol, 2009 Apr 20. PMID 19235874
    5. Expression Patterns of PACAP and PAC1R Genes and Anorexigenic Action of PACAP1 and PACAP2 in Zebrafish. Nakamachi T, et al. Front Endocrinol (Lausanne), 2019. PMID 31031705, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish.
      Title: Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish.
    2. A nanomolar dose of PACAP-38 inhibits neutrophil migration towards damaged zebrafish hair cells undergoing chemically induced necrosis and consequent inflammation. CuSO4 exposure up-regulated the expression of IL-8, IL-1beta, IL-6 and ATF3, while after PACAP-38 co-treatment expression levels of these genes were significantly decreased.
      Title: Pituitary adenylate cyclase-activating polypeptide (PACAP-38) plays an inhibitory role against inflammation induced by chemical damage to zebrafish hair cells.
    3. study reveals the distribution of immunoreactive GHRH-like peptide in structures of the zebrafish brain; results suggest involvement of GHRH-LP in both neuroendocrine and feeding-associated nervous circuits
      Title: Distribution of growth hormone-releasing hormone-like peptide: Immunoreactivity in the central nervous system of the adult zebrafish (Danio rerio).
    4. expression of transcripts for PACAP and its receptors by 0.5-6 hpf make both PACAP1 and PACAP2 candidates for factors that influence brain development
      Title: Role of two genes encoding PACAP in early brain development in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101522

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pituitary adenylate cyclase activating polypeptide activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenylate cyclase activating polypeptide 1b
    Names
    (zf)PACAP38-2
    PACAP38-2
    growth hormone-releasing hormone

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272081.1 → NP_001259010.1  adenylate cyclase activating polypeptide 1b isoform 2 precursor

      See identical proteins and their annotated locations for NP_001259010.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BX927088, EH439402
      UniProtKB/TrEMBL
      A0A8M1P449, Q5XJ02
      Related
      ENSDARP00000060811.4, ENSDART00000060812.5
      Conserved Domains (1) summary
      pfam00123
      Location:96 → 122
      Hormone_2; Peptide hormone

    2. NM_214715.2 → NP_999880.1  adenylate cyclase activating polypeptide 1b isoform 1 precursor

      See identical proteins and their annotated locations for NP_999880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      BX927088, EH442184
      UniProtKB/TrEMBL
      A0A2R8Q4S7, B2GQT7, Q98TU3
      Related
      ENSDARP00000033245.5, ENSDART00000034784.7
      Conserved Domains (1) summary
      pfam00123
      Location:131 → 157
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      31297150..31302661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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