shc1 SHC (Src homology 2 domain containing) transforming protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: shc1provided by ZNC
Official Full Name: SHC (Src homology 2 domain containing) transforming protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2538
See related: Ensembl:ENSDARG00000075437 AllianceGenome:ZFIN:ZDB-GENE-030131-2538
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc10h03; si:dkey-246i14.4
Summary: Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within angiogenesis. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (22782010..22863395, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (22866624..22948043, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that adaptor protein Shc is required for angiogenesis in zebrafish (accession number LOC563639), mice, and human vascular endothelial cell-culture models.
Title: The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis.

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Pathways from PubChem

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General gene information

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Markers

fc10h03.x1 (e-PCR)
- UniSTS:192475

fc10h03.x1 (e-PCR)
- UniSTS:192476

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SHC (Src homology 2 domain containing) transforming protein 1; SHC-transforming protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

22782010..22863395 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005169756.5 → XP_005169813.1 SHC-transforming protein 1 isoform X4

UniProtKB/TrEMBL

A0A8M2BH44, E9QCZ8

Related

ENSDARP00000123188.1, ENSDART00000147609.3

Conserved Domains (2) summary

cd09925
Location:346 → 449

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:35 → 206

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
XM_005169755.5 → XP_005169812.1 SHC-transforming protein 1 isoform X3

UniProtKB/TrEMBL

A0A8M2BH05, E7F3T0

Related

ENSDARP00000089171.4, ENSDART00000098400.5

Conserved Domains (2) summary

cd09925
Location:351 → 454

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:40 → 211

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
XM_009292293.4 → XP_009290568.1 SHC-transforming protein 1 isoform X2

UniProtKB/TrEMBL

A0A8M3AJ37

Conserved Domains (2) summary

cd09925
Location:472 → 575

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:179 → 332

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
XM_017351494.3 → XP_017206983.1 SHC-transforming protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M6Z1Z9