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    pabpc1a poly(A) binding protein, cytoplasmic 1a [ Danio rerio (zebrafish) ]

    Gene ID: 606498, updated on 12-Sep-2024

    Summary

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    Official Symbol
    pabpc1aprovided by ZNC
    Official Full Name
    poly(A) binding protein, cytoplasmic 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3238
    See related
    Ensembl:ENSDARG00000017219 AllianceGenome:ZFIN:ZDB-GENE-030131-3238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pabpc1; PABP-1A; wu:fb16a02; wu:fi19b08; wu:fj12d09; wu:fj61f06; zgc:109879
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Acts upstream of or within heart development. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in several structures, including blastodisc; digestive system; eye; pectoral fin bud; and ventral mesenchyme. Orthologous to several human genes including PABPC1 (poly(A) binding protein cytoplasmic 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See pabpc1a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (54829283..54851248)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (55121197..55143081)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene pleckstrin homology-like domain family B member 1 Neighboring gene nuclear receptor subfamily 0, group B, member 2a Neighboring gene keratinocyte differentiation factor 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans. Flamand MN, et al. Nucleic Acids Res, 2016 Jul 8. PMID 27095199, Free PMC Article
    2. Zebrafish fin regeneration involves transient serotonin synthesis. König D, et al. Wound Repair Regen, 2019 Jul. PMID 31017740
    3. Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish. Mishima Y, et al. Proc Natl Acad Sci U S A, 2012 Jan 24. PMID 22232654, Free PMC Article
    4. Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Hosono Y, et al. Cell, 2017 Dec 14. PMID 29245011, Free PMC Article
    5. RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Yang Y, et al. Mol Cell, 2019 Sep 19. PMID 31399345

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    polyadenylate-binding protein 1A
    Names
    poly A binding protein, cytoplasmic 1 a
    poly(A)-binding protein 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031676.1 → NP_001026846.1  polyadenylate-binding protein 1A

      See identical proteins and their annotated locations for NP_001026846.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099992
      UniProtKB/TrEMBL
      Q499B6
      Related
      ENSDARP00000021064.7, ENSDART00000024729.9
      Conserved Domains (1) summary
      TIGR01628
      Location:11 → 614
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      54829283..54851248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169771.5 → XP_005169828.1  polyadenylate-binding protein 1A isoform X1

      UniProtKB/Swiss-Prot
      F1QB54, Q499B6, Q6P5M4
      Related
      ENSDARP00000124828.1, ENSDART00000148392.2
      Conserved Domains (1) summary
      TIGR01628
      Location:11 → 614
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1QB54.1 GenPept UniProtKB/Swiss-Prot:F1QB54

    Gene LinkOut

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