appa amyloid beta (A4) precursor protein a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: appaprovided by ZNC
Official Full Name: amyloid beta (A4) precursor protein aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000616-13
See related: Ensembl:ENSDARG00000104279 AllianceGenome:ZFIN:ZDB-GENE-000616-13
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: app; zgc:85740; im:7044540; wu:fj08a12; wu:fj34d10; wu:fk65e12
Summary: Predicted to enable heparin binding activity; serine-type endopeptidase inhibitor activity; and transition metal ion binding activity. Acts upstream of or within central nervous system development; convergent extension; and vasculature development. Predicted to be located in Golgi-associated vesicle and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; nervous system; pleuroperitoneal region; segmental plate; and solid lens vesicle. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (617799..656820, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (622620..661614, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish.
Title: The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish.
Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and central nervous system development.
Title: Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development.
A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.
Title: Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth.
these results indicate the Appa-RFP and Aplp2 fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.
Title: Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins.
Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD), does not.
Title: Amyloid precursor protein is required for convergent-extension movements during Zebrafish development.
expression pattern during embryonic development
Title: Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development.

Submit: New GeneRIF Correction

General gene information

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Markers

fc42a09.y1 (e-PCR)
- UniSTS:193796

fd36d10.y1 (e-PCR)
- UniSTS:195422

fk65e12.x1 (e-PCR)
- UniSTS:201375

fj34d10.x1 (e-PCR)
- UniSTS:199156

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of non-motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi-associated vesicle	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: amyloid beta (A4) precursor protein a

Names: amyloid beta precursor protein a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131564.3 → NP_571639.1 amyloid beta (A4) precursor protein a precursor

See identical proteins and their annotated locations for NP_571639.1

Status: VALIDATED

Source sequence(s)

CT704552, EH115273, EH435990, EH444060, FO704780, FP067437

UniProtKB/TrEMBL

Q6NUZ1

Related

ENSDARP00000136859.1, ENSDART00000166786.2

Conserved Domains (7) summary

smart00006
Location:28 → 189

A4_EXTRA; amyloid A4

pfam00014
Location:293 → 343

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam02177
Location:32 → 132

APP_N; Amyloid A4 N-terminal heparin-binding

pfam03494
Location:643 → 681

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:684 → 734

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:134 → 189

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:349 → 531

APP_E2; E2 domain of amyloid precursor protein