exo1 exonuclease 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: exo1provided by ZNC
Official Full Name: exonuclease 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2828
See related: Ensembl:ENSDARG00000056832 AllianceGenome:ZFIN:ZDB-GENE-040426-2828
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc16e04; zgc:55521; wu:fc16e04
Summary: Predicted to enable 5'-flap endonuclease activity and single-stranded DNA 5'-3' exodeoxyribonuclease activity. Predicted to be involved in DNA recombination and mismatch repair. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be active in nucleus. Is expressed in proliferative region. Orthologous to human EXO1 (exonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (22565703..22573305, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (22545867..22553469, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc16e04.x1 (e-PCR)
- UniSTS:192794

fi28e03.x1 (e-PCR)
- UniSTS:197184

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 5'-3' DNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-3' DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 5'-flap endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables flap endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA 5'-3' DNA exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in mismatch repair	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: exonuclease 1

Names: exonuclease I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213469.1 → NP_998634.1 exonuclease 1

See identical proteins and their annotated locations for NP_998634.1

Status: PROVISIONAL

Source sequence(s)

BC044187

UniProtKB/Swiss-Prot

Q803U7

Related

ENSDARP00000073846.4, ENSDART00000079390.6

Conserved Domains (2) summary

cd09908
Location:213 → 289

H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease

cd09857
Location:1 → 206

PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs