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    aldh9a1a.1 aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100005587, updated on 18-Sep-2024

    Summary

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    Official Symbol
    aldh9a1a.1provided by ZNC
    Official Full Name
    aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1257
    See related
    Ensembl:ENSDARG00000069100 AllianceGenome:ZFIN:ZDB-GENE-030131-1257
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    TMABADH; TMABA-DH; aldh9a1a; aldh9a1l; wu:fb64d09
    Summary
    Predicted to enable 4-trimethylammoniobutyraldehyde dehydrogenase activity and aminobutyraldehyde dehydrogenase activity. Predicted to be involved in cellular aldehyde metabolic process and protein homotetramerization. Predicted to be located in cytosol. Is expressed in gut; head mesenchyme; intestinal bulb; and liver. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See aldh9a1a.1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (21095125..21103467, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (21063040..21071432, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene zgc:112962 Neighboring gene aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 2 Neighboring gene transmembrane and coiled-coil domains 1 Neighboring gene uridine-cytidine kinase 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Lyche JL, et al. Aquat Toxicol, 2011 Apr. PMID 21356182
    2. Early embryonic gene expression profiling of zebrafish prion protein (Prp2) morphants. Nourizadeh-Lillabadi R, et al. PLoS One, 2010 Oct 22. PMID 21042590, Free PMC Article
    3. Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish. Lyche JL, et al. J Toxicol Environ Health A, 2010. PMID 20526952
    4. Differential protein profile in zebrafish (Danio rerio) brain under the joint exposure of methyl parathion and cadmium. Ling XP, et al. Environ Sci Pollut Res Int, 2012 Nov. PMID 22767353
    5. Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish. Zhao Y, et al. Sci Total Environ, 2020 Mar 25. PMID 31918190

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56131, MGC77427

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-trimethylammoniobutyraldehyde dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminobutyraldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnitine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular aldehyde metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    4-trimethylaminobutyraldehyde dehydrogenase A
    Names
    aldehyde dehydrogenase 9 family, member A1 like 1
    aldehyde dehydrogenase 9 family, member A1a.1
    aldehyde dehydrogenase 9A1a
    aldehyde dehydrogenase family 9 member A1-A
    NP_958879.1
    XP_005166831.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201471.1 → NP_958879.1  4-trimethylaminobutyraldehyde dehydrogenase A

      See identical proteins and their annotated locations for NP_958879.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045932
      UniProtKB/Swiss-Prot
      Q6NYB3, Q7ZVB2
      UniProtKB/TrEMBL
      B0S7W4
      Related
      ENSDARP00000118280.1, ENSDART00000137838.3
      Conserved Domains (1) summary
      cd07090
      Location:45 → 502
      ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      21095125..21103467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166774.4 → XP_005166831.1  4-trimethylaminobutyraldehyde dehydrogenase A isoform X1

      See identical proteins and their annotated locations for XP_005166831.1

      UniProtKB/Swiss-Prot
      Q6NYB3, Q7ZVB2
      UniProtKB/TrEMBL
      B0S7W4
      Related
      ENSDARP00000091056.3, ENSDART00000100283.5
      Conserved Domains (1) summary
      cd07090
      Location:45 → 502
      ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394720.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      129586..139327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZVB2.1 GenPept UniProtKB/Swiss-Prot:Q7ZVB2

    Gene LinkOut

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