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    slc4a1a solute carrier family 4 member 1a (Diego blood group) [ Danio rerio (zebrafish) ]

    Gene ID: 84703, updated on 12-Sep-2024

    Summary

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    Official Symbol
    slc4a1aprovided by ZNC
    Official Full Name
    solute carrier family 4 member 1a (Diego blood group)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010525-1
    See related
    Ensembl:ENSDARG00000012881 AllianceGenome:ZFIN:ZDB-GENE-010525-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ae1; band3; slc4a1; zgc:111889; zgc:152771; si:dz180g5.1
    Summary
    Predicted to enable anion:anion antiporter activity and bicarbonate transmembrane transporter activity. Acts upstream of or within anion transport; embryonic hemopoiesis; and erythrocyte differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including erythroid lineage cell; hematopoietic system; liver; mesoderm; and pleuroperitoneal region. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See slc4a1a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (20065861..20091960, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (19916121..19942220, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ataxin 7 like 3a Neighboring gene upstream binding transcription factor Neighboring gene selenoprotein W, 2b Neighboring gene selenoprotein W, 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogeny of anion exchangers: could trout AE1 conductive properties be shared by other members of the gene family? Guizouarn H, et al. Biochim Biophys Acta, 2005 Nov 30. PMID 16150548
    2. Cloning of the zebrafish retsina blood mutation: a genetic model for dyserythropoiesis and erythroid cytokinesis. Paw BH. Blood Cells Mol Dis, 2001 Jan-Feb. PMID 11358361
    3. Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish. Sun X, et al. PLoS One, 2009 Aug 12. PMID 19672293, Free PMC Article
    4. Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Paw BH, et al. Nat Genet, 2003 May. PMID 12669066
    5. Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone. Hailey DW, et al. PLoS Genet, 2012. PMID 23071446, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC152771

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 4 member 1a (Diego blood group)
    Names
    AE1/band 3
    erythroid anion exchanger 1
    ret
    retsina
    solute carrier family 4 (anion exchanger), member 1a (Diego blood group)
    solute carrier family 4, anion exchanger, member 1
    solute carrier family 4, anion exchanger, member 1a
    zAE1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198338.1 → NP_938152.1  solute carrier family 4 member 1a (Diego blood group)

      See identical proteins and their annotated locations for NP_938152.1

      Status: PROVISIONAL

      Source sequence(s)
      AF350072
      UniProtKB/TrEMBL
      A0A8M1PF13, F1RAE7, Q7ZZJ7
      Related
      ENSDARP00000032458.4, ENSDART00000029386.7
      Conserved Domains (3) summary
      TIGR00834
      Location:78 → 904
      ae; anion exchange protein
      pfam00955
      Location:356 → 844
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:106 → 309
      Band_3_cyto; Band 3 cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      20065861..20091960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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