dmrt3a doublesex and mab-3 related transcription factor 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dmrt3aprovided by ZNC
Official Full Name: doublesex and mab-3 related transcription factor 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021220-3
See related: Ensembl:ENSDARG00000035290 AllianceGenome:ZFIN:ZDB-GENE-021220-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dmrt3a1; zDmart3a; zgc:101766
Summary: Enables sequence-specific DNA binding activity. Acts upstream of or within swimming behavior. Predicted to be active in nucleus. Is expressed in nervous system; neural tube; and reproductive system. Orthologous to human DMRT3 (doublesex and mab-3 related transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (45000597..45003863)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (44400444..44403710)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Behavioral Characterization of dmrt3a Mutant Zebrafish Reveals Crucial Aspects of Vertebrate Locomotion through Phenotypes Related to Acceleration.
Title: Behavioral Characterization of dmrt3a Mutant Zebrafish Reveals Crucial Aspects of Vertebrate Locomotion through Phenotypes Related to Acceleration.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in male sex differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: doublesex- and mab-3-related transcription factor 3a

Names: Dmrt3; dmrt7a; doublesex and mab-3 related transcription factor 3a-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005779.2 → NP_001005779.2 doublesex- and mab-3-related transcription factor 3a

See identical proteins and their annotated locations for NP_001005779.2

Status: VALIDATED

Source sequence(s)

BX255951

UniProtKB/Swiss-Prot

A2BFC1, P83758, Q4VUS9, Q5XJM6, Q694V7, Q9DD75

Related

ENSDARP00000051145.1, ENSDART00000051146.2

Conserved Domains (2) summary

cd14419
Location:221 → 263

CUE_DMA_DMRTA3; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3)

pfam00751
Location:24 → 70

DM; DM DNA binding domain