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    lpcat4 lysophosphatidylcholine acyltransferase 4 [ Danio rerio (zebrafish) ]

    Gene ID: 327566, updated on 12-Sep-2024

    Summary

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    Official Symbol
    lpcat4provided by ZNC
    Official Full Name
    lysophosphatidylcholine acyltransferase 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5777
    See related
    Ensembl:ENSDARG00000035028 AllianceGenome:ZFIN:ZDB-GENE-030131-5777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77292; wu:fb10c07; wu:fi17g10
    Summary
    Predicted to enable acyltransferase activity and calcium ion binding activity. Predicted to be involved in phospholipid metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in EVL. Orthologous to human LPCAT4 (lysophosphatidylcholine acyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See lpcat4 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (1473939..1495964)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (1337859..1359884)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene cylindromatosis (turban tumor syndrome) 3 Neighboring gene uncharacterized LOC137496114 Neighboring gene ER membrane protein complex subunit 4 Neighboring gene uncharacterized LOC137496113 Neighboring gene NOP10 ribonucleoprotein homolog (yeast)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat. Zhang J, et al. Environ Pollut, 2020 Nov. PMID 32798906
    2. n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterolhomeostasis in fish. Zhao Y, et al. Appl Microbiol Biotechnol, 2020 Mar. PMID 31950220
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-acylglycerophosphocholine O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysophospholipid acyltransferase LPCAT4
    NP_991122.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205559.2 → NP_991122.2  lysophospholipid acyltransferase LPCAT4

      Status: VALIDATED

      Source sequence(s)
      CU905505, EH483770, EH541464, FP139120
      UniProtKB/TrEMBL
      A0A8M1PGC0, F1QD35
      Related
      ENSDARP00000050686.5, ENSDART00000050687.6
      Conserved Domains (2) summary
      cd07991
      Location:85 → 291
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:42 → 305
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      1473939..1495964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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