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    ppiab peptidylprolyl isomerase Ab (cyclophilin A) [ Danio rerio (zebrafish) ]

    Gene ID: 335519, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ppiabprovided by ZNC
    Official Full Name
    peptidylprolyl isomerase Ab (cyclophilin A)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7459
    See related
    Ensembl:ENSDARG00000103994 AllianceGenome:ZFIN:ZDB-GENE-030131-7459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ppial; zgc:73102; zgc:86688; wu:fj18g05
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within response to hypoxia. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in brain. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See ppiab in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (45345574..45352279)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (45498962..45505667)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) glycohydrolase, like Neighboring gene zinc finger, MIZ-type containing 2 Neighboring gene RING finger protein 122 Neighboring gene kinesin-like protein KIF2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transient, flexible gene editing in zebrafish neutrophils and macrophages for determination of cell-autonomous functions. Isiaku AI, et al. Dis Model Mech, 2021 Jul 1. PMID 34296745, Free PMC Article
    2. Hif-1α-Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish. Ogryzko NV, et al. J Immunol, 2019 Jan 15. PMID 30552162, Free PMC Article
    3. The afc antifungal activity cluster, which is under tight regulatory control of ShvR, is essential for transition from intracellular persistence of Burkholderia cenocepacia to acute pro-inflammatory infection. Gomes MC, et al. PLoS Pathog, 2018 Dec. PMID 30513124, Free PMC Article
    4. Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation. Mesureur J, et al. PLoS Pathog, 2017 Jun. PMID 28651010, Free PMC Article
    5. Inhibition of macrophage migration in zebrafish larvae demonstrates in vivo efficacy of human CCR2 inhibitors. Sommer F, et al. Dev Comp Immunol, 2021 Mar. PMID 33238180

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidylprolyl isomerase Ab (cyclophilin A)
    Names
    cyclophilin
    peptidylprolyl isomerase A, like
    NP_001315353.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328424.1 → NP_001315353.1  peptidylprolyl isomerase Ab (cyclophilin A)

      Status: VALIDATED

      Source sequence(s)
      CF998539, EH487851, FP074878
      UniProtKB/TrEMBL
      A0A0R4IM14, Q6IQN4, Q6PC53
      Related
      ENSDARP00000134856.1, ENSDART00000166085.2
      Conserved Domains (1) summary
      cd01926
      Location:4 → 162
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      45345574..45352279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199957.1: Suppressed sequence

      Description
      NM_199957.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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