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    sae1 SUMO1 activating enzyme subunit 1 [ Danio rerio (zebrafish) ]

    Gene ID: 415148, updated on 12-Sep-2024

    Summary

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    Official Symbol
    sae1provided by ZNC
    Official Full Name
    SUMO1 activating enzyme subunit 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-21
    See related
    Ensembl:ENSDARG00000010487 AllianceGenome:ZFIN:ZDB-GENE-040625-21
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sae2a; uble1a; fa28b04; zgc:86633; wu:fa28b04
    Summary
    Predicted to enable SUMO activating enzyme activity and protein C-terminus binding activity. Acts upstream of or within definitive hemopoiesis; hematopoietic stem cell homeostasis; and protein sumoylation. Predicted to be located in nucleus. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in brain. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See sae1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23722627..23739104)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (23787362..23803836)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene zgc:154093 Neighboring gene zinc finger CCCH-type containing 4 Neighboring gene BCL2 binding component 3 Neighboring gene RAD1 homolog (S. pombe)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3α. Zhang P, et al. Am J Physiol Regul Integr Comp Physiol, 2012 Dec. PMID 23034716
    2. SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish. Li X, et al. Development, 2012 Dec 1. PMID 23132242
    3. The tumor-associated YB-1 protein: new player in the circadian control of cell proliferation. Pagano C, et al. Oncotarget, 2017 Jan 24. PMID 28008157, Free PMC Article
    4. Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish. Yuan H, et al. Sci Rep, 2015 Mar 11. PMID 25757417, Free PMC Article
    5. Insights into the evolution of the ISG15 and UBA7 system. Liu S, et al. Genomics, 2022 Mar. PMID 35134494

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. sae1 is essential for the maintenance of hematopoietic stem/progenitor cells during fetal hematopoiesis in zebrafish.
      Title: SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SUMO activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to SUMO activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification by small protein conjugation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SUMO activating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SUMO activating enzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SUMO-activating enzyme subunit 1
    Names
    SUMO1 activating enzyme subunit 2a
    ubiquitin-like 1 (sentrin) activating enzyme E1A
    ubiquitin-like 1-activating enzyme E1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002058.1 → NP_001002058.1  SUMO-activating enzyme subunit 1

      See identical proteins and their annotated locations for NP_001002058.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071328
      UniProtKB/Swiss-Prot
      Q6IQS6
      Related
      ENSDARP00000016138.8, ENSDART00000011447.9
      Conserved Domains (2) summary
      cd01492
      Location:17 → 343
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:20 → 167
      ThiF; ThiF family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      23722627..23739104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481377.2 → XP_021337052.1  SUMO-activating enzyme subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q099
      Conserved Domains (1) summary
      cd01492
      Location:17 → 170
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IQS6.1 GenPept UniProtKB/Swiss-Prot:Q6IQS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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