klf4 Kruppel like factor 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: klf4provided by ZNC
Official Full Name: Kruppel like factor 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-111014-1
See related: Ensembl:ENSDARG00000079922 AllianceGenome:ZFIN:ZDB-GENE-111014-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: klf4a
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of cell population proliferation and stem cell proliferation. Is expressed in several structures, including EVL; digestive system; ectoderm; heart; and nervous system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (Kruppel like factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (387396..435466, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (437845..485915, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration.
Title: Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration.
experiments delineate novel roles for Klf4 in regulating the ionocyte progenitor population throughout early stem cell stage to initiation of terminal differentiation, which is dependent on Dlc-Notch-mediated lateral inhibition
Title: Zebrafish Klf4 maintains the ionocyte progenitor population by regulating epidermal stem cell proliferation and lateral inhibition.
zebrafih Klf4a is essential for the repression of intestinal cell proliferation
Title: Zebrafish krüppel-like factor 4a represses intestinal cell proliferation and promotes differentiation of intestinal cell lineages.
Proper heart valve formation in zebrafish critically depends on protein kinase D2-histone deacetylase 5-Kruppel-like factor signaling.
Title: Protein kinase D2 controls cardiac valve formation in zebrafish by regulating histone deacetylase 5 activity.

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General gene information

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Markers

z9956 (e-PCR), detects polymorphism
- UniSTS:238184

Z9956 (e-PCR)
- UniSTS:50834

fk65c08.x1 (e-PCR)
- UniSTS:201364

NoName (e-PCR)
- UniSTS:238303

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Krueppel-like factor 4

Names: Kruppel-like factor 4a; Kruppel-like transcription factor 4a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113483.1 → NP_001106955.1 Krueppel-like factor 4

See identical proteins and their annotated locations for NP_001106955.1

Status: PROVISIONAL

Source sequence(s)

DQ679226

UniProtKB/TrEMBL

A9X6Q5

Related

ENSDARP00000097662.3, ENSDART00000110297.4

Conserved Domains (4) summary

COG5048
Location:320 → 375

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:315 → 337

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:313 → 337

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:359 → 384

zf-H2C2_2; Zinc-finger double domain