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    crim1 cysteine rich transmembrane BMP regulator 1 (chordin-like) [ Danio rerio (zebrafish) ]

    Gene ID: 404210, updated on 12-Sep-2024

    Summary

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    Official Symbol
    crim1provided by ZNC
    Official Full Name
    cysteine rich transmembrane BMP regulator 1 (chordin-like)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040312-2
    See related
    Ensembl:ENSDARG00000029668 AllianceGenome:ZFIN:ZDB-GENE-040312-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc29f08
    Summary
    Predicted to enable insulin-like growth factor binding activity and serine-type endopeptidase inhibitor activity. Acts upstream of or within blood vessel development; notochord morphogenesis; and somitogenesis. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; intermediate cell mass of mesoderm; notochord; otic vesicle; and posterior segment eye. Used to study cataract and microphthalmia. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See crim1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (38929275..39184408, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (38981690..39236823, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene D-glutamate cyclase Neighboring gene solute carrier family 24 member 4a Neighboring gene zgc:174356 Neighboring gene small nucleolar RNA SNORA47 Neighboring gene glutamyl-prolyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A High-Throughput Assay for Congenital and Age-Related Eye Diseases in Zebrafish. Brastrom LK, et al. Biomedicines, 2019 Apr 11. PMID 30979021, Free PMC Article
    2. Invertebrate hematopoiesis: an astakine-dependent novel hematopoietic factor. Lin X, et al. J Immunol, 2011 Feb 15. PMID 21220699
    3. Functional and evolutionary insights from the Ciona notochord transcriptome. Reeves WM, et al. Development, 2017 Sep 15. PMID 28928284, Free PMC Article
    4. Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development. Kinna G, et al. Mech Dev, 2006 Apr. PMID 16524703
    5. Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Thomas-Jinu S, et al. Neuron, 2017 Apr 19. PMID 28392072, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. primary role of zebrafish crim1 is likely to be the regulation of somitic and vascular development
      Title: Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within notochord morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich motor neuron 1 protein
    Names
    CRIM-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212821.1 → NP_997986.1  cysteine-rich motor neuron 1 protein precursor

      See identical proteins and their annotated locations for NP_997986.1

      Status: PROVISIONAL

      Source sequence(s)
      AY151045
      UniProtKB/Swiss-Prot
      Q7T3Q2
      Related
      ENSDARP00000050533.4, ENSDART00000050534.6
      Conserved Domains (4) summary
      smart00214
      Location:330 → 384
      VWC; von Willebrand factor (vWF) type C domain
      pfam00219
      Location:33 → 84
      IGFBP; Insulin-like growth factor binding protein
      pfam02822
      Location:561 → 586
      Antistasin; Antistasin family
      cl17735
      Location:812 → 866
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      38929275..39184408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T3Q2.1 GenPept UniProtKB/Swiss-Prot:Q7T3Q2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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