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    Elp1 elongator acetyltransferase complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140934, updated on 10-Jul-2024

    Summary

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    Symbol
    Elp1provided by RGD
    Full Name
    elongator acetyltransferase complex subunit 1provided by RGD
    Primary source
    RGD:620072
    See related
    EnsemblRapid:ENSRNOG00000016725 AllianceGenome:RGD:620072
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ikbkap
    Summary
    Enables ATP binding activity and protein kinase activity. Involved in I-kappaB phosphorylation. Predicted to be located in cytoplasm. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Riley-Day syndrome; asthma; medulloblastoma; and scoliosis. Orthologous to human ELP1 (elongator acetyltransferase complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 190.0), Adrenal (RPKM 185.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elp1 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (76248545..76300985, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (71453338..71505833, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (73503406..73552798, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene actin-like 7b Neighboring gene actin-like 7a Neighboring gene actin binding transcription modulator Neighboring gene catenin alpha-like 1 Neighboring gene transmembrane protein 245

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of bradykinin receptors in rat bronchi via I kappa B kinase-mediated inflammatory signaling pathway. Lei Y, et al. Eur J Pharmacol, 2010 May 25. PMID 20184874
    2. Norepinephrine increases I kappa B alpha expression in astrocytes. Gavrilyuk V, et al. J Biol Chem, 2002 Aug 16. PMID 12050158
    3. Orthopaedic manifestations of familial dysautonomia. A review of one hundred and thirty-six patients. Bar-On E, et al. J Bone Joint Surg Am, 2000 Nov. PMID 11097445
    4. The role of the IKAP gene polymorphisms in atopic diseases in the middle European population. Schüller M, et al. J Hum Genet, 2003. PMID 12774215
    5. Measurement of IKK activity in primary rat T cells: rapid activation and inactivation. Kupfer R, et al. J Immunol Methods, 2002 Aug 1. PMID 12133632

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of elongator holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of elongator holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    elongator complex protein 1
    Names
    IKK complex-associated protein
    elongator complex protein 1-like
    ikappaB kinase complex-associated protein
    inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein
    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080899.2 → NP_543175.2  elongator complex protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q8VHU4
      UniProtKB/TrEMBL
      A6KDR5, F1LP76
      Related
      ENSRNOP00000022836.5, ENSRNOT00000022836.7
      Conserved Domains (3) summary
      COG0457
      Location:874 → 1099
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00039
      Location:112 → 147
      7WD40; WD40 repeat [structural motif]
      pfam04762
      Location:1 → 953
      IKI3; IKI3 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      76248545..76300985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109191.2 → XP_038965119.1  elongator complex protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8VHU4
      Conserved Domains (3) summary
      COG0457
      Location:874 → 1099
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00039
      Location:112 → 147
      7WD40; WD40 repeat [structural motif]
      pfam04762
      Location:1 → 953
      IKI3; IKI3 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHU4.1 GenPept UniProtKB/Swiss-Prot:Q8VHU4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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