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    EEF2K eukaryotic elongation factor 2 kinase [ Homo sapiens (human) ]

    Gene ID: 29904, updated on 28-Oct-2024

    Summary

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    Official Symbol
    EEF2Kprovided by HGNC
    Official Full Name
    eukaryotic elongation factor 2 kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:24615
    See related
    Ensembl:ENSG00000103319 MIM:606968; AllianceGenome:HGNC:24615
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    eEF-2K; CaMKIII; HSU93850
    Summary
    This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 21.4), fat (RPKM 10.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EEF2K in Genome Data Viewer
    Location:
    16p12.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (22206278..22288738)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (21928475..22010936, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22217599..22300059)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 42E, member 2 Neighboring gene uncharacterized LOC124903666 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:22196551-22197050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:22201633-22202132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7263 Neighboring gene tRNA-Leu (anticodon TAG) 3-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:22221261-22221761 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43156 Neighboring gene GATA motif-containing MPRA enhancer 198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:22229709-22230208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:22237029-22237652 Neighboring gene Sharpr-MPRA regulatory region 4253 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:22308474-22309018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7267 Neighboring gene Sharpr-MPRA regulatory region 3906 Neighboring gene tRNA-Leu (anticodon AAG) 2-4 Neighboring gene RNA polymerase III subunit E Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:22333033-22333580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:22333581-22334130 Neighboring gene uncharacterized LOC124903664

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Roles of eEF-2 kinase in cancer. Liu XY, et al. Chin Med J (Engl), 2012 Aug. PMID 22932089
    2. Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and Its Role in Substrate Recognition. Piserchio A, et al. J Mol Biol, 2019 Jul 12. PMID 31108082, Free PMC Article
    3. Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro. Yu P, et al. Acta Pharmacol Sin, 2019 Sep. PMID 30914761, Free PMC Article
    4. Elongation factor-2 kinase (eEF-2K) expression is associated with poor patient survival and promotes proliferation, invasion and tumor growth of lung cancer. Bircan HA, et al. Lung Cancer, 2018 Oct. PMID 30268477
    5. Interplay between reversible phosphorylation and irreversible ADP-ribosylation of eukaryotic translation elongation factor 2. Mateus-Seidl R, et al. Biol Chem, 2019 Mar 26. PMID 30218597, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease.
      Title: Roles of eukaryotic elongation factor 2 kinase (eEF2K) in neuronal plasticity, cognition, and Alzheimer disease.
    2. Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.
      Title: Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.
    3. eEF2K promotes PD-L1 stabilization through inactivating GSK3beta in melanoma.
      Title: eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma.
    4. miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
      Title: miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
    5. Novel regulation of the eEF2K/eEF2 pathway: prospects of 'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'.
      Title: Novel regulation of the eEF2K/eEF2 pathway: prospects of 'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'.
    6. eEF2K as a novel metastatic and prognostic biomarker in gastric cancer patients.
      Title: eEF2K as a novel metastatic and prognostic biomarker in gastric cancer patients.
    7. Targeting eukaryotic elongation factor-2 kinase suppresses the growth and peritoneal metastasis of ovarian cancer.
      Title: Targeting eukaryotic elongation factor-2 kinase suppresses the growth and peritoneal metastasis of ovarian cancer.
    8. Structural dynamics of the complex of calmodulin with a minimal functional construct of eukaryotic elongation factor 2 kinase and the role of Thr348 autophosphorylation.
      Title: Structural dynamics of the complex of calmodulin with a minimal functional construct of eukaryotic elongation factor 2 kinase and the role of Thr348 autophosphorylation.
    9. Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells.
      Title: Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells.
    10. eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA.
      Title: eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA.
    Submit: New GeneRIF Correction See all GeneRIFs (65)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC45041

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables elongation factor-2 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables elongation factor-2 kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables translation factor activity, RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to anoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to brain-derived neurotrophic factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myosin II filament disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation at postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to prolactin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic elongation factor 2 kinase
    Names
    alternative protein EEF2K
    calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase
    calmodulin-dependent protein kinase III
    eEF-2 kinase
    elongation factor-2 kinase
    eukaroytic elongation factor 2 kinase
    NP_037434.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013302.5 → NP_037434.2  eukaryotic elongation factor 2 kinase

      Status: REVIEWED

      Source sequence(s)
      AC009034
      Consensus CDS
      CCDS10604.1
      UniProtKB/Swiss-Prot
      O00418, Q8N588
      UniProtKB/TrEMBL
      A0AAG2TFE4
      Related
      ENSP00000263026.5, ENST00000263026.10
      Conserved Domains (3) summary
      COG0790
      Location:533 → 713
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:547 → 576
      SLR; SLR repeat [structural motif]
      cd16967
      Location:103 → 318
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      22206278..22288738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_017852933.1 Reference GRCh38.p14 PATCHES

      Range
      816312..898761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      21928475..22010936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00418.2 GenPept UniProtKB/Swiss-Prot:O00418

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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