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    IL20RB interleukin 20 receptor subunit beta [ Homo sapiens (human) ]

    Gene ID: 53833, updated on 28-Oct-2024

    Summary

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    Official Symbol
    IL20RBprovided by HGNC
    Official Full Name
    interleukin 20 receptor subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:6004
    See related
    Ensembl:ENSG00000174564 MIM:605621; AllianceGenome:HGNC:6004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIRS1; FNDC6; IL-20R2
    Summary
    IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
    Expression
    Biased expression in skin (RPKM 54.3) and esophagus (RPKM 20.8) See more
    Orthologs
    mouse all
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    Genomic context

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    See IL20RB in Genome Data Viewer
    Location:
    3q22.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (136957983..137011085)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (139698644..139751732)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136676825..136729927)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20591 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:136587915-136588414 Neighboring gene solute carrier family 35 member G2 Neighboring gene NCK1 divergent transcript Neighboring gene RAD51AP1 pseudogene 1 Neighboring gene MPRA-validated peak4840 silencer Neighboring gene NCK adaptor protein 1 Neighboring gene IL20RB antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 14292 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:136725903-136726404 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:136741910-136742410 Neighboring gene MPRA-validated peak4841 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:136751222-136752088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:136930163-136930662 Neighboring gene VISTA enhancer hs208 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:137038167-137039366 Neighboring gene VISTA enhancer hs209 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:137050490-137051689 Neighboring gene VISTA enhancer hs210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:137179051-137179600 Neighboring gene VISTA enhancer hs653 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20598 Neighboring gene RNA, 5S ribosomal pseudogene 142 Neighboring gene MTCH2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. IL-20: biological functions and clinical implications. Wei CC, et al. J Biomed Sci, 2006 Sep. PMID 16703417
    2. Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma. Keller KE, et al. J Ocul Pharmacol Ther, 2014 Mar-Apr. PMID 24455976, Free PMC Article
    3. Interleukin 20 receptor subunit beta (IL20RB) predicts poor prognosis and regulates immune cell infiltration in clear cell renal cell carcinoma. Zhang H, et al. BMC Genom Data, 2022 Jul 26. PMID 35883015, Free PMC Article
    4. Association analysis of IL20RA and IL20RB genes in psoriasis. Kingo K, et al. Genes Immun, 2008 Jul. PMID 18480827
    5. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. Dumoutier L, et al. J Immunol, 2001 Oct 1. PMID 11564763

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interleukin 20 receptor subunit beta (IL20RB) predicts poor prognosis and regulates immune cell infiltration in clear cell renal cell carcinoma.
      Title: Interleukin 20 receptor subunit beta (IL20RB) predicts poor prognosis and regulates immune cell infiltration in clear cell renal cell carcinoma.
    2. Trabecular meshwork cells express IL-20 receptors; Mutation of the T104 residue in IL-20R2 leads to a reduction in STAT3 phosphorylation as well as decreased matrix metalloproteinase activity
      Title: Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma.
    3. The crystal structure of the IL-20/IL-20R1/IL-20R2 complex reveals how type I and II complexes discriminate cognate from noncognate ligands
      Title: Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines.
    4. crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54%
      Title: Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex.
    5. Complete mda-7/IL-24 receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2) are seldom expressed in liver cancer cell lines.
      Title: Expression pattern of mda-7/IL-24 receptors in liver cancer cell lines.
    6. The hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis and single nucleotide polymorphisms (SNPs) in the IL20RA and IL20RB genes in psoriasis patients were investigated.
      Title: Association analysis of IL20RA and IL20RB genes in psoriasis.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association analysis of IL20RA and IL20RB genes in psoriasis.
    8. forms stable complex with interleukin-19 and interleukin-20 [IL-20R1][IL-20R2]
      Title: Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association study of co-occurring anxiety in major depression.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC34923

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-20 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CD8-positive, alpha-beta T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homeostasis of number of cells within a tissue IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response-inhibiting signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-2 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of type IV hypersensitivity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-20 receptor subunit beta
    Names
    IL-20 receptor subunit beta
    IL-20R-beta
    IL-20RB
    fibronectin type III domain containing 6
    interleukin 20 receptor beta subunit
    interleukin-20 receptor II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144717.4 → NP_653318.2  interleukin-20 receptor subunit beta precursor

      See identical proteins and their annotated locations for NP_653318.2

      Status: VALIDATED

      Source sequence(s)
      AY358305, BC063696
      Consensus CDS
      CCDS3093.1
      UniProtKB/Swiss-Prot
      B4DL40, Q6P438, Q6UXL0, Q8IYY5, Q8TAJ7
      Related
      ENSP00000328133.4, ENST00000329582.9
      Conserved Domains (2) summary
      pfam01108
      Location:30 → 124
      Tissue_fac; Tissue factor
      cl21522
      Location:136 → 225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      136957983..137011085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512911.3 → XP_011511213.1  interleukin-20 receptor subunit beta isoform X2

      See identical proteins and their annotated locations for XP_011511213.1

      Conserved Domains (1) summary
      cl21522
      Location:1 → 77
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_011512910.4 → XP_011511212.1  interleukin-20 receptor subunit beta isoform X1

      Conserved Domains (2) summary
      pfam01108
      Location:35 → 129
      Tissue_fac; Tissue factor
      cl21522
      Location:141 → 230
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_017006632.1 → XP_016862121.1  interleukin-20 receptor subunit beta isoform X2

      Conserved Domains (1) summary
      cl21522
      Location:1 → 77
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. XM_006713665.5 → XP_006713728.1  interleukin-20 receptor subunit beta isoform X2

      See identical proteins and their annotated locations for XP_006713728.1

      Conserved Domains (1) summary
      cl21522
      Location:1 → 77
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      139698644..139751732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346901.1 → XP_054202876.1  interleukin-20 receptor subunit beta isoform X2

    2. XM_054346900.1 → XP_054202875.1  interleukin-20 receptor subunit beta isoform X1

    3. XM_054346903.1 → XP_054202878.1  interleukin-20 receptor subunit beta isoform X2

    4. XM_054346902.1 → XP_054202877.1  interleukin-20 receptor subunit beta isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UXL0.1 GenPept UniProtKB/Swiss-Prot:Q6UXL0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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