GPRASP1 G protein-coupled receptor associated sorting protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPRASP1provided by HGNC
Official Full Name: G protein-coupled receptor associated sorting protein 1provided by HGNC
Primary source: HGNC:HGNC:24834
See related: Ensembl:ENSG00000198932 MIM:300417; AllianceGenome:HGNC:24834
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GASP; GASP1; GASP-1
Summary: This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010]
Expression: Broad expression in brain (RPKM 27.6), ovary (RPKM 20.3) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq22.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (102651483..102659083)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (101096438..101104038)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (101906411..101914011)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPRASP1 is a candidate anti-oncogene and correlates with immune microenvironment and immunotherapeutic efficiency in head and neck cancer.
Title: GPRASP1 is a candidate anti-oncogene and correlates with immune microenvironment and immunotherapeutic efficiency in head and neck cancer.
Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer.
Title: Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer.
G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker, promotes proliferation and invasion of triple negative breast cancer.
Title: G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker, promotes proliferation and invasion of triple negative breast cancer.
Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1
Title: Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1.
Data suggest that specific serine/threonine residues in DRD2 (dopamine receptor D2) are involved in regulation of DRD2 endocytosis by GRK2 (G-protein coupled receptor kinase 2) and GASP1.
Title: ARF6 and GASP-1 are post-endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine D₂ receptors mediated by GRK and PKC in transfected cells.
GASP1 was identified as a potential new serum and biomarker for brain, pancreatic, lung, and breast cancers, and gliomas.
Title: G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker.
GASP-1 is a key regulator of the trafficking and, by extension, functional expression of GPR55
Title: The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.
LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression.
Title: Strength training with blood flow restriction diminishes myostatin gene expression.
These studies identify GASP-1 as a potential new serum and tumor biomarker for breast cancer.
Title: G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer.
following this endocytosis the D(3) dopamine receptors fail to recycle and are instead targeted for degradation through an interaction with the G protein-coupled receptor (GPCR)-associated sorting protein-1 (GASP-1)
Title: Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Readthrough ARMCX5-GPRASP2

Readthrough gene: ARMCX5-GPRASP2, Included gene: ARMCX5, Included gene: GPRASP3, Included gene: GPRASP2, Included gene: LINC00630

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor catabolic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G-protein coupled receptor-associated sorting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_021332.1 RefSeqGene

Range

5118..12718

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001099410.2 → NP_001092880.1 G-protein coupled receptor-associated sorting protein 1

See identical proteins and their annotated locations for NP_001092880.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' UTR and encodes the same protein, as compared to variant 1.

Source sequence(s)

AW293629, AY044233, BC114552, DA104338

Consensus CDS

CCDS35352.1

UniProtKB/Swiss-Prot

O43168, Q5JY77, Q96LA1

Related

ENSP00000393691.1, ENST00000415986.5

Conserved Domains (1) summary

pfam04826
Location:1167 → 1390

Arm_2; Armadillo-like
NM_001099411.2 → NP_001092881.1 G-protein coupled receptor-associated sorting protein 1

See identical proteins and their annotated locations for NP_001092881.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two exons in the 5' UTR and encodes the same protein, as compared to variant 1.

Source sequence(s)

AW293629, AY044233, BC114552, DA094297

Consensus CDS

CCDS35352.1

UniProtKB/Swiss-Prot

O43168, Q5JY77, Q96LA1

Related

ENSP00000409420.1, ENST00000444152.5

Conserved Domains (1) summary

pfam04826
Location:1167 → 1390

Arm_2; Armadillo-like
NM_001184727.2 → NP_001171656.1 G-protein coupled receptor-associated sorting protein 1

See identical proteins and their annotated locations for NP_001171656.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an additional exon in the 5' UTR and encodes the same protein, as compared to variant 1.

Source sequence(s)

AW293629, AY044233, BC114552, BX489726, BX954816

Consensus CDS

CCDS35352.1

UniProtKB/Swiss-Prot

O43168, Q5JY77, Q96LA1

Related

ENSP00000445683.1, ENST00000537097.2

Conserved Domains (1) summary

pfam04826
Location:1167 → 1390

Arm_2; Armadillo-like
NM_014710.5 → NP_055525.3 G-protein coupled receptor-associated sorting protein 1

See identical proteins and their annotated locations for NP_055525.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents a dominant transcript. Variants 1-4 encode the same protein.

Source sequence(s)

AW293629, AY044233, BC114552, DA222893

Consensus CDS

CCDS35352.1

UniProtKB/Swiss-Prot

O43168, Q5JY77, Q96LA1

Related

ENSP00000355146.4, ENST00000361600.9

Conserved Domains (1) summary

pfam04826
Location:1167 → 1390

Arm_2; Armadillo-like