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    SFT2D2 SFT2 domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 375035, updated on 14-Nov-2024

    Summary

    Official Symbol
    SFT2D2provided by HGNC
    Official Full Name
    SFT2 domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:25140
    See related
    Ensembl:ENSG00000213064 AllianceGenome:HGNC:25140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNQ512; dJ747L4.C1.2
    Summary
    Predicted to be involved in protein transport and vesicle-mediated transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 9.9), bone marrow (RPKM 8.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SFT2D2 in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (168226004..168253021)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (167577504..167604523)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (168195242..168222259)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene ribosomal protein L34 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9777 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168195163-168195896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2059 Neighboring gene ankyrin repeat domain 36B pseudogene 1 Neighboring gene RNA, U6 small nuclear 1310, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168239605-168240105 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:168254423-168254924 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:168260049-168260620 Neighboring gene T-box transcription factor 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    General gene information

    Potential readthrough

    Included gene: TBX19

    Clone Names

    • FLJ34085

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in protein transport  
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in endomembrane system  
    located_in extracellular exosome PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in membrane  

    General protein information

    Preferred Names
    vesicle transport protein SFT2B
    Names
    SFT2 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199344.3NP_955376.1  vesicle transport protein SFT2B

      See identical proteins and their annotated locations for NP_955376.1

      Status: VALIDATED

      Source sequence(s)
      AK290325, AL009051, BC068098
      Consensus CDS
      CCDS1271.1
      UniProtKB/Swiss-Prot
      A8K2R0, O95562, Q6UWR8
      Related
      ENSP00000271375.3, ENST00000271375.7
      Conserved Domains (1) summary
      pfam04178
      Location:45155
      Got1; Got1/Sft2-like family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      168226004..168253021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      167577504..167604523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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