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    DCUN1D1 defective in cullin neddylation 1 domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 54165, updated on 2-Nov-2024

    Summary

    Official Symbol
    DCUN1D1provided by HGNC
    Official Full Name
    defective in cullin neddylation 1 domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:18184
    See related
    Ensembl:ENSG00000043093 MIM:605905; AllianceGenome:HGNC:18184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1
    Summary
    Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation and regulation of protein ubiquitination. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 16.2), bone marrow (RPKM 6.8) and 24 other tissues See more
    Orthologs
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    Genomic context

    See DCUN1D1 in Genome Data Viewer
    Location:
    3q26.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (182938074..182985918, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (185743177..185791010, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (182655862..182703706, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14932 Neighboring gene ATP11B divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:182516660-182517160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:182517161-182517661 Neighboring gene Sharpr-MPRA regulatory region 857 Neighboring gene ATPase phospholipid transporting 11B (putative) Neighboring gene EIF3E pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20883 Neighboring gene C9orf85 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14935 Neighboring gene uncharacterized LOC105374246 Neighboring gene uncharacterized LOC124906309 Neighboring gene methylcrotonyl-CoA carboxylase subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20884 Neighboring gene uncharacterized LOC105374247

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cullin family protein binding  
    enables cullin family protein binding PubMed 
    enables protein binding PubMed 
    enables ubiquitin conjugating enzyme binding  
    enables ubiquitin-like protein binding  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    part_of ubiquitin ligase complex  
    part_of ubiquitin ligase complex PubMed 

    General protein information

    Preferred Names
    DCN1-like protein 1
    Names
    DCN1, defective in cullin neddylation 1, domain containing 1
    DCUN1 domain-containing protein 1
    RP42 homolog
    defective in cullin neddylation protein 1-like protein 1
    squamous cell carcinoma-related oncogene

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308101.2NP_001295030.1  DCN1-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001295030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 5' exon, contains an alternate 5' terminal exon, and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC092953, AF292100, AK025764, AW103206, BC013163, BI828039, BU620603, HY052047
      Consensus CDS
      CCDS77862.1
      UniProtKB/TrEMBL
      B4DM76, C9JUW4, C9JVE2
      Related
      ENSP00000419359.1, ENST00000469954.5
      Conserved Domains (2) summary
      pfam03556
      Location:121231
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    2. NM_020640.4NP_065691.2  DCN1-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_065691.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC092953, AF292100, AK025764, AK297328, AW103206, BC013163, BU620603
      Consensus CDS
      CCDS3240.1
      UniProtKB/Swiss-Prot
      B2RB37, Q7L3G9, Q8TEX7, Q96GG9, Q9H6M1, Q9HCT3
      UniProtKB/TrEMBL
      B4DM76
      Related
      ENSP00000292782.4, ENST00000292782.9
      Conserved Domains (2) summary
      pfam03556
      Location:136246
      Cullin_binding; Cullin binding
      cl21463
      Location:151
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      182938074..182985918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453601.2XP_024309369.2  DCN1-like protein 1 isoform X4

    2. XM_047448339.1XP_047304295.1  DCN1-like protein 1 isoform X2

    3. XM_011512914.2XP_011511216.1  DCN1-like protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011511216.1

      Conserved Domains (2) summary
      pfam03556
      Location:121219
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    4. XM_011512915.3XP_011511217.1  DCN1-like protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011511217.1

      Conserved Domains (2) summary
      pfam03556
      Location:121219
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    5. XM_011512916.3XP_011511218.1  DCN1-like protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011511218.1

      Conserved Domains (2) summary
      pfam03556
      Location:121219
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    6. XM_047448340.1XP_047304296.1  DCN1-like protein 1 isoform X3

    7. XM_047448338.1XP_047304294.1  DCN1-like protein 1 isoform X1

    8. XM_011512912.3XP_011511214.1  DCN1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011511214.1

      Conserved Domains (2) summary
      pfam03556
      Location:136234
      Cullin_binding; Cullin binding
      cl21463
      Location:151
      UBA_like_SF; UBA domain-like superfamily
    9. XM_017006634.1XP_016862123.1  DCN1-like protein 1 isoform X3

      Conserved Domains (2) summary
      pfam03556
      Location:121219
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      185743177..185791010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346910.1XP_054202885.1  DCN1-like protein 1 isoform X5

      UniProtKB/TrEMBL
      C9JUW4, C9JVE2
    2. XM_054346906.1XP_054202881.1  DCN1-like protein 1 isoform X2

    3. XM_054346907.1XP_054202882.1  DCN1-like protein 1 isoform X3

    4. XM_054346909.1XP_054202884.1  DCN1-like protein 1 isoform X3

    5. XM_054346905.1XP_054202880.1  DCN1-like protein 1 isoform X1

    6. XM_054346904.1XP_054202879.1  DCN1-like protein 1 isoform X1

    7. XM_054346908.1XP_054202883.1  DCN1-like protein 1 isoform X3

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