fzd9b frizzled class receptor 9b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fzd9bprovided by ZNC
Official Full Name: frizzled class receptor 9bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000906-4
See related: Ensembl:ENSDARG00000014673 AllianceGenome:ZFIN:ZDB-GENE-000906-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fzx; fz11; fzd9; zg11; zehl0603; hm:zehl0603
Summary: Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Predicted to be involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Predicted to act upstream of or within cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; heart; lateral plate mesoderm; neural plate; and tail bud. Orthologous to human FZD9 (frizzled class receptor 9). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (41648842..41650587, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (41658650..41660395, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EGFR-dependent endocytosis of Wnt9a and Fzd9b promotes beta-catenin signaling during hematopoietic stem cell development in zebrafish.
Title: EGFR-dependent endocytosis of Wnt9a and Fzd9b promotes β-catenin signaling during hematopoietic stem cell development in zebrafish.
We demonstrate that the epidermal growth factor receptor (EGFR) is required as a cofactor for Wnt9a-Fzd9b signalling. EGFR-mediated phosphorylation of one tyrosine residue on the Fzd9b intracellular tail in response to Wnt9a promotes internalization of the Wnt9a-Fzd9b-LRP signalosome and subsequent signal transduction
Title: EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells.
frizzled 9 is a receptor for wnt8
Title: Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: frizzled-9b

Names: frizzled X; frizzled homolog 11; frizzled homolog 9; frizzled homolog 9b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131511.1 → NP_571586.1 frizzled-9b precursor

See identical proteins and their annotated locations for NP_571586.1

Status: PROVISIONAL

Source sequence(s)

AF169639

UniProtKB/TrEMBL

Q9I8V7

Related

ENSDARP00000006458.6, ENSDART00000024087.7

Conserved Domains (2) summary

cd07463
Location:33 → 159

CRD_FZ9; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 9 (Fz9) receptor

cd15036
Location:217 → 536

7tmF_FZD9; class F frizzled subfamily 9, member of 7-transmembrane G protein-coupled receptors