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    nr0b2a nuclear receptor subfamily 0, group B, member 2a [ Danio rerio (zebrafish) ]

    Gene ID: 403010, updated on 18-Sep-2024

    Summary

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    Official Symbol
    nr0b2aprovided by ZNC
    Official Full Name
    nuclear receptor subfamily 0, group B, member 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080403-1
    See related
    Ensembl:ENSDARG00000044685 AllianceGenome:ZFIN:ZDB-GENE-080403-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Nr0b2; SHP-A; NR0B2-A; gb:bc058069
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in circadian rhythm; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Is expressed in heart and yolk syncytial layer. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR0B2 (nuclear receptor subfamily 0 group B member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See nr0b2a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (54875532..54880550)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (55167507..55172525)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology-like domain family B member 1 Neighboring gene poly(A) binding protein, cytoplasmic 1a Neighboring gene keratinocyte differentiation factor 1a Neighboring gene trophoblast glycoprotein 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative genomics identifies genes mediating cardiotoxicity in the embryonic zebrafish heart. Chen J, et al. Physiol Genomics, 2008 Apr 22. PMID 18230668
    2. Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery. Zhang Y, et al. Front Mol Neurosci, 2022. PMID 35686059, Free PMC Article
    3. Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. Ma X, et al. Sci Adv, 2020 Jan. PMID 32064346, Free PMC Article
    4. The function of zebrafish gpbar1 in antiviral response and lipid metabolism. Xiong F, et al. Dev Comp Immunol, 2021 Mar. PMID 33285186
    5. Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the Notch pathway. Alghisi E, et al. Leukemia, 2013 Nov. PMID 23625115

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor subfamily 0 group B member 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256191.1 → NP_001243120.1  nuclear receptor subfamily 0 group B member 2a

      Status: PROVISIONAL

      Source sequence(s)
      BC058069
      UniProtKB/TrEMBL
      A0A8M1P4B4, F8W3I2, Q6PEG7
      Related
      ENSDARP00000124074.1, ENSDART00000149795.2
      Conserved Domains (1) summary
      cd07349
      Location:28 → 245
      NR_LBD_SHP; The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      54875532..54880550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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